Protein Alignment alphaTub84B and TUBB8

DIOPT Version :10

• Sequence 1: NP_476772.1
• Gene: alphaTub84B / 40848
• FlyBaseID: FBgn0003884
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_817124.1
• Gene: TUBB8 / 347688
• HGNCID: 20773
• Length: 444
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 178/450 - (39%)
• Similarity: 266/450 - (59%)
• Gaps: 12/450 - (2%)

  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRA 65
            |||.:...:||.|.|||...||:...||.|...|....|..:  ..:..|.:::|...|::||||
Human     1 MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHL--QLERINVYYNEASGGRYVPRA 63

  Fly    66 VFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCT 130
            |.|||||..:|.||:|.:.|:|.|:..|.|:..|.||:|:||||.|.|:::.|:|.:||.|:.|.
Human    64 VLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVVRKEAESCD 128

  Fly   131 GLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTL 195
            .||||.:.||.|||||||..:||:.::..:|..:....|:|.|:|:||..||||||:.|:.|..:
Human   129 CLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLI 193

  Fly   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV 260
            |::|..|.:||||:||||.:.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:...|:|
Human   194 ENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMV 258

  Fly   261 PYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVP 325
            |:||:||.:..:||:.|.....:..|:|||:|...|:..|.|..||||||:|:....::||.:..
Human   259 PFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMMAACDPRHGRYLTAAAIFRGRMPM 323

  Fly   326 KDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390
            ::|:..:..|:.|.:..|.||.|...|..:...||        ..::.:...:.|.|||.|.:.|
Human   324 REVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPP--------RGLKMSATFIGNNTAIQELFKR 380

  Fly   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEEY 450
            :..:|..|:.::||:|||.||||:|.||:||..::..|..:|::  ......|.|..|||
Human   381 VSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQ--YQDATAEEEEDEEY 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	173/437 (40%)
TUBB8	NP_817124.1	PTZ00010	1..427	CDD:240228	173/437 (40%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..444		4/17 (24%)