Protein Alignment alphaTub84B and TUBB8B

DIOPT Version :10

• Sequence 1: NP_476772.1
• Gene: alphaTub84B / 40848
• FlyBaseID: FBgn0003884
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001345618.1
• Gene: TUBB8B / 260334
• HGNCID: 24983
• Length: 444
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 175/450 - (38%)
• Similarity: 257/450 - (57%)
• Gaps: 12/450 - (2%)

  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRA 65
            |||.:....||.|.|||...||:...||.|...|....|..:  ..:..|....|...|::||||
Human     1 MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHL--QLERINVHHHEASGGRYVPRA 63

  Fly    66 VFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCT 130
            |.|||||..:|.|.:|.:.|:|.|:..|:|:..|.||:|:|.||.|.|:.:.|:|.:||.|:.|.
Human    64 VLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCD 128

  Fly   131 GLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTL 195
            .||||.:.||.|||||||..:||:.::..:|..:....|:|.|:|:||..||||||:.|:.|..:
Human   129 CLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLI 193

  Fly   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV 260
            |::|..|.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:...|:|
Human   194 ENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMV 258

  Fly   261 PYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVP 325
            |:||:||.:..:||:.|.....:..|:|||:|...|:..|.|..||||||.|:....::||.:..
Human   259 PFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMMAACDPRHGCYLTVAAIFRGRMPM 323

  Fly   326 KDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390
            ::|:..:..|:.|.:..|.||.|...|..:...||        ..::.:...:.|..||.|.:..
Human   324 REVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPP--------RGLKMSATFIGNNAAIQELFTC 380

  Fly   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEEY 450
            :..:|..|:.::||:|||.||||:|.||:||..::..|..:|::  ......|.|..|||
Human   381 VSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQ--YQDATAEEEEDEEY 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	170/437 (39%)
TUBB8B	NP_001345618.1	PLN00220	1..427	CDD:215107	170/437 (39%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..444		5/19 (26%)