DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub84B and atb2

DIOPT Version :9

Sequence 1:	NP_476772.1	Gene:	alphaTub84B / 40848	FlyBaseID:	FBgn0003884	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_595106.1	Gene:	atb2 / 2540936	PomBaseID:	SPBC800.05c	Length:	449	Species:	Schizosaccharomyces pombe

Alignment Length:	439	Identity:	340/439 - (77%)
Similarity:	391/439 - (89%)	Gaps:	0/439 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRA 65
            |||.|||||||||.||||||||||||||||||:|.|..:......|..|:|||||||.||:|||:
pombe     1 MREIISIHVGQAGTQIGNACWELYCLEHGIQPNGYMNPETASQNSDGGFSTFFSETGQGKYVPRS 65

  Fly    66 VFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCT 130
            ::|||||.|:|:||||.||.||||||||||||||:|||||||||:|||:||.|.|:||::||.|:
pombe    66 IYVDLEPNVIDQVRTGPYRDLFHPEQLITGKEDASNNYARGHYTVGKELVDEVTDKIRRIADNCS 130

  Fly   131 GLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTL 195
            ||||||:||||||||||||.:||:|||:::|.|||||:|::||||||||:|||||||:||||.||
pombe   131 GLQGFLVFHSFGGGTGSGFGALLLERLAMEYTKKSKLQFSVYPAPQVSTSVVEPYNSVLTTHATL 195

  Fly   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV 260
            :.:||.||||||:.|||||||||||||:|.||||||.|:||||||||||:|:|||||.|||||||
pombe   196 DLADCTFMVDNESCYDICRRNLDIERPSYENLNRLIAQVVSSITASLRFEGSLNVDLAEFQTNLV 260

  Fly   261 PYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVP 325
            ||||||||||||||::||.||:||..||.||||.||||.|||||||||.|:|||.|:||||||:|
pombe   261 PYPRIHFPLVTYAPIVSAAKAFHESNSVQEITNQCFEPYNQMVKCDPRAGRYMATCLLYRGDVIP 325

  Fly   326 KDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390
            :||.||:.|||.|||||||||||||||:||..:||..:.|.::|||.||||||||||:|||||:|
pombe   326 RDVQAAVTTIKAKRTIQFVDWCPTGFKIGICDRPPQHIEGSEIAKVDRAVCMLSNTTSIAEAWSR 390

  Fly   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDS 439
            |||||||||:|||||||||||||||||||||||||||||:||||||.||
pombe   391 LDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVGQDS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	338/437 (77%)
atb2	NP_595106.1	PTZ00335	1..448	CDD:185562	340/439 (77%)
atb2	NP_595106.1	alpha_tubulin	2..435	CDD:276955	334/432 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	346	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69045
Inparanoid	1	1.050	727	1.000	Inparanoid score	I91
OMA	1	1.010	-	-		QHG54134
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	1	1.000	-	-		mtm9275
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	1	1.100	-	-	LDO	PTHR11588
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2309
SonicParanoid	1	1.000	-	-		X95
TreeFam	0	0.000	Not matched by this tool.
	13	12.900