Protein Alignment alphaTub84B and TUBB

DIOPT Version :10

• Sequence 1: NP_476772.1
• Gene: alphaTub84B / 40848
• FlyBaseID: FBgn0003884
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001280141.1
• Gene: TUBB / 203068
• HGNCID: 20778
• Length: 464
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 179/458 - (39%)
• Similarity: 269/458 - (58%)
• Gaps: 20/458 - (4%)

  Fly     2 RECISIHVGQAGVQIGNAC-------WELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAG 59
            |..:..|.||....:.:|.       ||:...||||.|.|....|..:  ..|..:.:::|...|
Human    15 RSGVRDHPGQQSETLPHATFLQKIKFWEVISDEHGIDPTGTYHGDSDL--QLDRISVYYNEATGG 77

  Fly    60 KHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRK 124
            |:||||:.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||
Human    78 KYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRK 142

  Fly   125 LADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSIL 189
            .|:.|..||||.:.||.|||||||..:||:.::..:|..:....|::.|:|:||..||||||:.|
Human   143 EAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATL 207

  Fly   190 TTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTE 254
            :.|..:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:
Human   208 SVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRK 272

  Fly   255 FQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLY 319
            ...|:||:||:||.:..:||:.|.....:..|:|.|:|...|:..|.|..||||||:|:....::
Human   273 LAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVF 337

  Fly   320 RGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAI 384
            ||.:..|:|:..:..::.|.:..||:|.|...|..:...||        ..::.||..:.|:|||
Human   338 RGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMAVTFIGNSTAI 394

  Fly   385 AEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAR---EDLAALEKDYEEVGMDSGDGEGEG 446
            .|.:.|:..:|..|:.::||:|||.||||:|.||:||.   .||.:..:.|::...:..:..||.
Human   395 QELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEE 459

  Fly   447 AEE 449
            |||
Human   460 AEE 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	174/446 (39%)
TUBB	NP_001280141.1	PLN00220	39..449	CDD:215107	169/419 (40%)