DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tailor and Mtpap

DIOPT Version :9

Sequence 1:	NP_001262327.1	Gene:	Tailor / 40847	FlyBaseID:	FBgn0037470	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_080433.1	Gene:	Mtpap / 67440	MGIID:	1914690	Length:	585	Species:	Mus musculus

Alignment Length:	559	Identity:	122/559 - (21%)
Similarity:	208/559 - (37%)	Gaps:	167/559 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 MAAPGEGVAFVQPQELQ-------TIKRTFSCSSCSNRIVGT---------------TIAKAVAH 166
            |||.|.|:....|...|       :|.|..||.......:|:               |:.|..:.
Mouse     1 MAARGVGLLTRLPVCSQRRNRIPRSISRLLSCPGTIAASIGSEEQSSVVAETGIEDKTLQKKFSE 65

  Fly   167 LSEQHPK----------PNPNNQ-----------PVQPH-------------------------P 185
            :.::..:          ||..|:           ||..|                         .
Mouse    66 VQKERREQAQRTVLIHCPNNINEKKFLKYLSQHGPVNNHFFYESFGLFAVVEFCQKDSIKSLQNG 130

  Fly   186 THQTKQEKKQAQVKARQHITVRLPKKARAMIVGE-ITNVFKDKYPIADKLKVIPEY-DVIEQDL- 247
            ||...|..:.|.....:.:.:|| |...:.:.|: .........|.:.||..:..| :.||:.|
Mouse   131 THTPTQSTEAAIPFKSRFLNLRL-KNPSSQVSGQPFVQTTNQSPPSSKKLFELLSYAESIEEQLN 194

  Fly   248 -------------------CKLL----SPGFPKQPLRVYKFGSRITGIGNRSSDLDLFVDIGKSG 289
                               |.|:    :..||...:|  .|||.:...|....|||:|:|:.::|
Mouse   195 TLLKAFQLTEENIRLRHLTCSLIEDIAAAYFPSCVIR--PFGSSVNTFGKLGCDLDMFLDLDETG 257

  Fly   290 ------NTFHTF-EHRASNATVAKLRAMRKFFCDSEDWRLINF---------IEQARVPIIKTCH 338
                  ||.:.| |.:..|....::...:......|  .|.||         |..||.|:::..|
Mouse   258 KLDVHKNTGNFFMEFQVKNVPSERIATQKILSVIGE--CLDNFGPGCVGVQKILNARCPLVRFSH 320

  Fly   339 LPTGIECDICLNSMGFCNTNLLKYIFES-QPLTQYMCIYVKNWLERCKLTEQ-----ISTYSITL 397
            ..:|.:||:..|:.....::.|.||:.| ....:.:...|:.|.....||..     |:.:|:|:
Mouse   321 QGSGFQCDLTANNSIALKSSELLYIYGSLDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTV 385

  Fly   398 MVIYFLQLQALLPPI-----AMLQIEDAANQAVLVG---PWV--VNFAQKSFSELGLQQLKATVP 452
            |||:|||.::  |||     ::..|.||.::.:|.|   .:|  ||..|.|.:...|:.|
Mouse   386 MVIFFLQRRS--PPILPTLDSLKSIADAEDRCILEGNNCTFVQDVNKIQPSGNTETLELL----- 443

  Fly   453 VIKGFLRNFFAYFAKFDYEHFLVCPYIGQANVEIAKIERMLHARYSAYVSDNPECSIQLKKPMVV 517
                 ::.||.||..|.:..       ...|:...:.:            :.|:.|     |:.:
Mouse   444 -----IKEFFEYFGNFAFNK-------NSINIRQGREQ------------NKPDSS-----PLYI 479

  Fly   518 QDPIQLNHNVTKAVTKYGLQTFVDYCQQTAELLEEPSTN 556
            |:|.:.:.|::|.|::..||.||:..:.:|.:||:...|
Mouse   480 QNPFETSLNISKNVSQSQLQKFVELARDSAWILEQEDKN 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tailor	NP_001262327.1	DUF1439	<70..126	CDD:297551	1/1 (100%)
Tailor	NP_001262327.1	NT_PAP_TUTase	245..364	CDD:143392	36/158 (23%)
Mtpap	NP_080433.1	NT_PAP_TUTase	209..347	CDD:143392	36/141 (26%)
		PAP_assoc	441..486	CDD:281779	12/78 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12271
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870