DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tailor and Tut1

DIOPT Version :9

Sequence 1:	NP_001262327.1	Gene:	Tailor / 40847	FlyBaseID:	FBgn0037470	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001029073.1	Gene:	Tut1 / 499314	RGDID:	1561043	Length:	866	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	123/621 - (19%)
Similarity:	198/621 - (31%)	Gaps:	209/621 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 TTNPPQLDPHLANLLERIMVGIESYLDRNPTYVLPQEMAAPGEGVAFVQ--PQELQTIK-----R 144
            |.|.|.||.||.....|.:|.:.:            ...|.|....||.  |:::.:.:     :
  Rat    25 TANRPSLDAHLKGRKHRDLVQLRA------------TRKAQGLRSVFVSGFPRDVGSAQLSEYFQ 77

  Fly   145 TFSCSSCSNRI------------VGTTIAKAVAHLSEQHP------KPNPNNQ-----PVQPHP- 185
            ||  ...:|.:            :|...|:.......:|.      :..|..|     |....|
  Rat    78 TF--GPVANIVMDKDKGVFAIVEMGDISAREAVLSQPKHSLGGHTLRVRPREQKEFQSPASKSPK 140

  Fly   186 -----THQTKQE-KKQAQVKARQHITVRL------PKKARAMIVGEITNVFKDKYPIADKLKVIP 238
                 :||..|. .:.|.|.|:....|.|      .::.|.::|..:..||.:.:|
  Rat   141 GVDSNSHQLAQALAEAADVGAQMVKLVELRELSEAERQLRTLVVALMQEVFTEFFP--------- 196

  Fly   239 EYDVIEQDLCKLLSPGFPKQPLRVYKFGSRITGIGNRSSDLDLFVDIG------KSGNTFHTFEH 297
                                ...|:.|||.:........|||||:|:|      ....|....|.
  Rat   197 --------------------GCVVHPFGSSVNSFDVHGCDLDLFLDLGDMEEPQPDPQTPKLPEA 241

  Fly   298 RASNATVAKLRAMRKFFC-----DS------EDWRLINF-------------------------- 325
            .:.::|:|.....:...|     ||      :|...::|
  Rat   242 SSLDSTLASSLDPQVLACTPASLDSLSPTSLQDSEALDFETPSSLAPQTPDSALGSDTVTSPQSL 306

  Fly   326 -------------------------------------------------------IEQARVPIIK 335
                                                                   :..||.|::|
  Rat   307 PPVSPLEEDRGEGKHRKELELAEASKDEKEEATAVLELVGSILRGCVPGVYRVQTVPSARRPVVK 371

  Fly   336 TCHLPTGIECDICL-NSMGFCNTNLLKYIFESQPLTQYMCIYVKNWLERCKLT---EQISTYSIT 396
            .||.|:|:..||.| |.:...|:..|....|.....:.:...::.|.:...|:   ..::.|::|
  Rat   372 FCHRPSGLHGDISLSNRLALYNSRFLNLCSEMDSRVRPLVYTLRCWAQHNGLSGGGPLLNNYALT 436

  Fly   397 LMVIYFLQLQ--ALLPPIAMLQIEDAANQAVLVGPWVVNFAQKSFSELGLQQLKATVPVIKGFLR 459
            |:||||||.:  .:||.:|.|.......:.|.|..|..:| .|..|.|   :....|..:...|.
  Rat   437 LLVIYFLQTRDPPVLPTVAQLTQRSGEGEQVEVDGWDCSF-PKDASRL---EPSTNVEPLSSLLA 497

  Fly   460 NFFAYFAKFDYEHFLVCPYIGQANVEIAKIERMLHARYSAYVSDNPECSIQLKKPMVVQDPIQLN 524
            .||:..:.:|....|:....|||.:....:.           ||..| .::| .||.:|||..|:
  Rat   498 QFFSCVSCWDLSGSLLSLREGQALMVAGGLP-----------SDLWE-GLRL-GPMNLQDPFDLS 549

  Fly   525 HNVTKAVTKYGLQTFVDYCQQTAELLEEPSTNWRQR 560
            |||...||....:.....|...|....  |..::||
  Rat   550 HNVAANVTSRVAKRLQSSCGAAASYCR--SLQYQQR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tailor	NP_001262327.1	DUF1439	<70..126	CDD:297551	9/38 (24%)
Tailor	NP_001262327.1	NT_PAP_TUTase	245..364	CDD:143392	34/217 (16%)
Tut1	NP_001029073.1	ZnF_U1	14..47	CDD:197732	9/21 (43%)
		RRM_TUT1	54..127	CDD:240725	11/74 (15%)
		RRM	<56..>140	CDD:223796	12/85 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..147		4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..249		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..321		2/53 (4%)
		NT_PAP_TUTase	<331..401	CDD:143392	14/69 (20%)
		PAP_assoc	491..550	CDD:281779	18/71 (25%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250\|UniProtKB:Q9H6E5	599..866
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..687
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..755
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1188122at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12271
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880