DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tailor and Tut4

DIOPT Version :9

Sequence 1:	NP_001262327.1	Gene:	Tailor / 40847	FlyBaseID:	FBgn0037470	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	XP_036019916.1	Gene:	Tut4 / 230594	MGIID:	2445126	Length:	1660	Species:	Mus musculus

Alignment Length:	339	Identity:	83/339 - (24%)
Similarity:	140/339 - (41%)	Gaps:	92/339 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 EYDVIEQDLCKLLSPGFPKQPLRVYKFGSRITGIGNRSSDLDLFVDIGKSGNTFHTFE-HRASNA 302
            |||                :..|:..|||...|.|.|.||||:.:          |.| |..:..
Mouse  1003 EYD----------------EKARLCLFGSSKNGFGFRDSDLDICM----------TLEGHENAEK 1041

  Fly   303 TVAK--LRAMRKFFCDSEDWRLINFIEQARVPIIKTCHLPTGIECDICL-NSMGFCNTNLLKYIF 364
            ...|  :..:.|........|.|..|..|:|||:|..|..:|:|.||.| |::...||.:|....
Mouse  1042 LNCKEIIENLAKILKRHPGLRNILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYA 1106

  Fly   365 ESQPLTQYMCIYVKNWLERCKLTE----QISTYSITLMVIYFLQLQALLPPIAMLQ----IEDAA 421
            ...|..||:...:|.:.:||.:.:    .:|:|:..|||:|||| |...|.|.:||    :||..
Mouse  1107 AIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYAYILMVLYFLQ-QRKPPVIPVLQEQINLEDII 1170

  Fly   422 NQAV---------LVGPWVVNFAQKSFSELGLQQLKATVPVI-----------KGFLRNFFAYFA 466
            ...:         :|..|...|..|:      ::||..:|.:           .|.||   .|..
Mouse  1171 PNEIFDGKQIPQRMVDGWNAFFFDKT------EELKKRLPSLGKNTESLGELWLGLLR---FYTE 1226

  Fly   467 KFDYEHFLVCPYIGQANVEIAKIERMLHARYSAYVSDNPECSIQLKKPMVVQDPIQLNHN----V 527
            :||::.:::       ::...|:......::::             |.:.::||..||||    |
Mouse  1227 EFDFKEYVI-------SIRQKKLLTTFEKQWTS-------------KCIAIEDPFDLNHNLGAGV 1271

  Fly   528 TKAVTKYGLQTFVD 541
            ::.:|.:.::.|::
Mouse  1272 SRKMTNFIMKAFIN 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tailor	NP_001262327.1	DUF1439	<70..126	CDD:297551
Tailor	NP_001262327.1	NT_PAP_TUTase	245..364	CDD:143392	34/122 (28%)
Tut4	XP_036019916.1	rad2	<2..>366	CDD:273166
		TUTase	285..621	CDD:408858
		PAP_assoc	648..697	CDD:397761
		TRF4	946..>1289	CDD:227585	83/339 (24%)
		NT_PAP_TUTase	988..1106	CDD:143392	37/128 (29%)
		AIR1	<1304..>1393	CDD:227414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810