DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufl1 and Ufl1

DIOPT Version :9

Sequence 1:	NP_001246957.1	Gene:	Ufl1 / 40843	FlyBaseID:	FBgn0037467	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001342441.1	Gene:	Ufl1 / 67490	MGIID:	1914740	Length:	793	Species:	Mus musculus

Alignment Length:	826	Identity:	295/826 - (35%)
Similarity:	472/826 - (57%)	Gaps:	80/826 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||...:.|:||||||:|||..|:.::.||||.|.||||||||..:.:|
Mouse     1 MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||:.||.....|....:.|.:||||||||:|:..:::|:|:|
Mouse    66 MRDELHVRGGRVNIVDLQQVINVDLTHIESRVSDIIKSEKHVQMVLGQLIDENYLDQLSEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|::|||...:|||.|||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
Mouse   131 LQESGQVTVSELCKAYDLPGDFLTQALTQR-LGRIINGHLDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:::...|:     |..:|..:.:||.||::||:.||:|
Mouse   195 SAITRPTPVNSLVSKYGFQEQLLYSVLEDLVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.:||:|::.|.:.|:||...:|..||: .|..::.|..::..::
Mouse   260 FFRQNGYLEFDALSRLGIPDAVNYIKKRYKNTQLLFLKATCVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQAL--------A 377
            |::.:|||:||.||...:...:|.......|..|:.|.:|.|:.::..    |..|        |
Mouse   324 DISPLLPSSLSVEDAAMLLQQVMRPFGKLASAIVFSDTVVVSEKFITD----CTGLFSERMHQKA 384

  Fly   378 ESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGR 438
            |.:.|   :..|:  .|.|:.|.|   :|..|..:..|.||:|||||||:.|    :.|||...|
Mouse   385 EKEMK---NNPVH--LITEEDLKQ---ISILESVNTSKKDKKDERRKKATEGSGSVRGGGGGNAR 441

  Fly   439 ETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLE--- 500
            |.|.|.|||..|       ..:|.||..|.|.||    ||  ||       ||..:....:|
Mouse   442 EYKIKKTKKKGR-------KDEDSDDESQSSHGG----KK--KP-------DITFMFQDEIEDCL 486

  Fly   501 ----EEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQ---TNRRQTHAAIQDRINTLLIDIR 558
                ::..|.....:|.......|:..|...:.:|.::..   |.|::|...:|:.::.|..:||
Mouse   487 RKHIQDAPEEFISELAEYLIKPLNKMYLEVVRSVFMSSTSASGTGRKRTIKDLQEEVSNLYNNIR 551

  Fly   559 LYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRNKLAQECEA 622
            |:|||:|.|..||||.|.|:|||::..:|.|.:..::||:..:.|:. ..:..|.|.|:..:...
Mouse   552 LFEKGMKYFADDTQTALTKHLLKTVCTDITNLMFNFLASDFLMAVEEPAAITSDIRKKILSKLTE 616

  Fly   623 QYRAALLEQNKALN-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEP 686
            :.:.||.:.:.:|| |||:||....::..:.|.:::||.|||::|.::..|::.|.:||....:|
Mouse   617 ETKVALTKLHNSLNEKSIEDFLSCLDSATEACDIMVKKGDKKRERQILFQHRQALCEQLKVTEDP 681

  Fly   687 ALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVLQA------ 745
            ||:|||.|::||...|.|:|||.|:.|..|:..:...:.|||:.||::|..||::.|.:
Mouse   682 ALILHLTAVLLFQLSTHSMLHAPGRCVPQIIAFLHSKIPEDQHTLLVKYQGLVVKQLVSQNKKTG 746

  Fly   746 ---IPDSNE--------SKLANEHLQTMQNQVVELAQNFSRASISK 780
               .|.|:|        :....:.||.:...:.:|.....::|:::
Mouse   747 QGEDPSSDELDKEQHDVTNATRKELQELSLSIKDLVLKSRKSSVTE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	126/268 (47%)
Ufl1	NP_001342441.1	Required for E3 UFM1-protein ligase activity. /evidence=ECO:0000250\|UniProtKB:O94874	2..212		102/209 (49%)
		Mediates interaction with DDRGK1. /evidence=ECO:0000250\|UniProtKB:O94874	2..200		97/197 (49%)
		E3_UFM1_ligase	7..275	CDD:370652	129/272 (47%)
		Involved in CDK5RAP3-binding. /evidence=ECO:0000250\|UniProtKB:O94874	121..250		53/133 (40%)
		Mediates interaction with TRIP4. /evidence=ECO:0000250\|UniProtKB:O94874	200..400		68/212 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..473		28/66 (42%)
		Mediates interaction with CDK5RAP3. /evidence=ECO:0000250\|UniProtKB:B2GV24	490..683		58/204 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..765		6/39 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850183
Domainoid	1	1.000	274	1.000	Domainoid score	I1771
eggNOG	1	0.900	-	-		E1_KOG2235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9093
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1402
Isobase	1	0.950	-	0	Normalized mean entropy	S6103
OMA	1	1.010	-	-		QHG55411
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006174
OrthoInspector	1	1.000	-	-		oto95042
orthoMCL	1	0.900	-	-		OOG6_103555
Panther	1	1.100	-	-	LDO	PTHR31057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2878
SonicParanoid	1	1.000	-	-		X5107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740