DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufl1 and UFL1

DIOPT Version :9

Sequence 1:	NP_001246957.1	Gene:	Ufl1 / 40843	FlyBaseID:	FBgn0037467	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_056138.1	Gene:	UFL1 / 23376	HGNCID:	23039	Length:	794	Species:	Homo sapiens

Alignment Length:	813	Identity:	290/813 - (35%)
Similarity:	471/813 - (57%)	Gaps:	53/813 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||.....|:||||||:|||..|:.::.||||.|.||||||||..:.:|
Human     1 MADAWEEIRRLAADFQRAQFAEATQRLSERNCIEIVNKLIAQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||..||.....|....:.|.|||||||||:|:..:|:|:|:|
Human    66 MRDELHVRGGRVNIVDLQQVINVDLIHIENRIGDIIKSEKHVQLVLGQLIDENYLDRLAEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|:||||...:|||.:||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
Human   131 LQESGQVTISELCKTYDLPGNFLTQALTQR-LGRIISGHIDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:|:..:|:     |..:|..:.:||.||::||:.||:|
Human   195 SAITRPTAVNSLISKYGFQEQLLYSVLEELVNSGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.|||:|::...:.|:||...:|..||: .|..::.|..::..::
Human   260 FFRQNGYLEFDALSRLGIPDAVSYIKKRYKTTQLLFLKAACVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQALAESQAKAAI 385
            |:..:||::||.||...:...:|.......|..|:.|.:|.|:.::....:..:.|...:|:..:
Human   324 DIAPLLPTSLSVEDAAILLQQVMRAFSKQASTVVFSDTVVVSEKFINDCTELFRELMHQKAEKEM 388

  Fly   386 DGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGRETKTKSTK 446
            ..... ..|.|:.|.|   :||.|.....|.||:||||:||:.|    :.|||...||.|.|..|
Human   389 KNNPV-HLITEEDLKQ---ISTLESVSTSKKDKKDERRRKATEGSGSMRGGGGGNAREYKIKKVK 449

  Fly   447 KHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKP-LELVKTADIVKLITASLEEEGLEHLSKS 510
            |..|       ..||.||..|.|..|    ||  || :..:...:|...:...:::...|.:|:
Human   450 KKGR-------KDDDSDDESQSSHTG----KK--KPEISFMFQDEIEDFLRKHIQDAPEEFISE- 500

  Fly   511 IASLYTNQFNQTALARAQELFEATPQ----TNRRQTHAAIQDRINTLLIDIRLYEKGLKLFPQDT 571
            :|.......|:|.|...:.:|.::..    |.|::|...:|:.::.|..:|||:|||:|.|..||
Human   501 LAEYLIKPLNKTYLEVVRSVFMSSTTSASGTGRKRTIKDLQEEVSNLYNNIRLFEKGMKFFADDT 565

  Fly   572 QTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRNKLAQECEAQYRAALLEQNKAL 635
            |..|.|:||||:..:|.|.:..::||:..:.|.: ..:..:.|.|:..:...:.:.||.:.:.:|
Human   566 QAALTKHLLKSVCTDITNLIFNFLASDLMMAVDDPAAITSEIRKKILSKLSEETKVALTKLHNSL 630

  Fly   636 N-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEPALLLHLAALILFT 699
            | |||:||....::..:.|.:::|:.|||::|.::..|::.|.:||....:|||:|||.:::||.
Human   631 NEKSIEDFISCLDSAAEACDIMVKRGDKKRERQILFQHRQALAEQLKVTEDPALILHLTSVLLFQ 695

  Fly   700 TITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVLQA---------IPDSNE---- 751
            ..|.|:|||.|:.|..|:..:...:.|||:|||::|..||::.|.:         .|.:||
Human   696 FSTHSMLHAPGRCVPQIIAFLNSKIPEDQHALLVKYQGLVVKQLVSQSKKTGQGDYPLNNELDKE 760

  Fly   752 ----SKLANEHLQTMQNQVVELAQNFSRASISK 780
                :....:.||.:.:.:.:|.....::|:::
Human   761 QEDVASTTRKELQELSSSIKDLVLKSRKSSVTE 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	129/268 (48%)
UFL1	NP_056138.1	Required for E3 UFM1-protein ligase activity. /evidence=ECO:0000269\|PubMed:20018847	2..212		104/210 (50%)
		Mediates interaction with DDRGK1. /evidence=ECO:0000269\|PubMed:25219498	2..200		100/198 (51%)
		E3_UFM1_ligase	7..275	CDD:370652	129/268 (48%)
		Involved in CDK5RAP3-binding. /evidence=ECO:0000269\|PubMed:20164180	121..250		53/129 (41%)
		Mediates interaction with TRIP4. /evidence=ECO:0000269\|PubMed:25219498	200..400		63/201 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..473		31/78 (40%)
		Mediates interaction with CDK5RAP3. /evidence=ECO:0000250\|UniProtKB:B2GV24	490..684		56/194 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..770		3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159814
Domainoid	1	1.000	273	1.000	Domainoid score	I1798
eggNOG	1	0.900	-	-		E1_KOG2235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9093
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1440
Isobase	1	0.950	-	0	Normalized mean entropy	S6103
OMA	1	1.010	-	-		QHG55411
OrthoDB	1	1.010	-	-		D244863at33208
OrthoFinder	1	1.000	-	-		FOG0006174
OrthoInspector	1	1.000	-	-		oto91458
orthoMCL	1	0.900	-	-		OOG6_103555
Panther	1	1.100	-	-	LDO	PTHR31057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2878
SonicParanoid	1	1.000	-	-		X5107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750