DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufl1 and ufl-1

DIOPT Version :9

Sequence 1:	NP_001246957.1	Gene:	Ufl1 / 40843	FlyBaseID:	FBgn0037467	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_501090.1	Gene:	ufl-1 / 177471	WormBaseID:	WBGene00015555	Length:	735	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	194/789 - (24%)
Similarity:	341/789 - (43%)	Gaps:	135/789 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLEREIQ 67
            :.|.:|::||:|.|:.||:.:.:||||.||:|::..|:....::||:|.||..|:|.:|||.||:
Worm     2 TSWADIQKLASDLQRVQLSQSSKKLSEVNCIEVLQKLIASHRIDVVYTRDGHSYVTKNHLETEIK 66

  Fly    68 DELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEKLV 132
            :|....||||:|.:::..||:|...||..:..|.:.:....:...::...:|:..:..|:...|.
Worm    67 NECIAAGGRASLTDIAVALNIDFDHIEKTSRLIVSTDDEFTISNAEIFATEYVHRLRNELRTLLD 131

  Fly   133 QRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGALAA 197
            ::|..:.:.|...::|.|:.||..::||......:|..|..   ..:|.:::...:..:|..|.|
Worm   132 EQGNQTTAALCKHWNLSSELLQSLLIEKLGSSDFQGVVDGD---TIYTSSFLNARQLVLRAILIA 193

  Fly   198 ITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQVTSKQANSQ------YVPHIYAKTQADWVNSF 256
            :|:...::.|.:::|:..|.|:...:.:...|::......|:      |.|.:|.......|.:.
Worm   194 LTKITPISTIQKRVGLTPKRFWIAFENLQSLGEIPGTLIGSRTSPSCSYRPMMYDHLVKSCVLNQ 258

  Fly   257 YKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEF---LYLKRVALGARLVEL---TVVTALNECSA 315
            |:||.|||...::.||: |||..:.:...:.||   :.::.:.:...|::.   .|...|.:...
Worm   259 YRQNEFLEISTLKTLGV-DAKPALEEVLGSSEFKKLVSMRSMFMTKELMDQCINAVQEDLQKSGI 322

  Fly   316 TKQYLDLTTI-LPSNLSEEDIEEVFSTIM-AQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQALAE 378
            :..:|.|.:: ||.:.::||  |:.|.:. .:|.|:     :.:|.||....|.:.::....|.:
Worm   323 SDVHLALQSLNLPLDTADED--EIGSKVANVEKDSH-----FAEGFVFKGAVLTEALRSIDKLLD 380

  Fly   379 SQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSGKAGGGAQGRETKTK 443
            .:|...:|                                    |.:|...|.||
Worm   381 VRAHEEVD------------------------------------RLEAEKKKQGG---------- 399

  Fly   444 STKKHQRGKAA--AQFDSDDEDDAQQGSRGG-------GGASKKAVKPLELVKTADIVKLITASL 499
                   .|||  .|.::||..|.::|.:||       .|.||.:........:|:|      |:
Worm   400 -------AKAAVKVQEETDDWGDGKKGGKGGKKNAKSVKGGSKSSAPSTSSNLSANI------SI 451

  Fly   500 EEEGLE-------HLSKSIASLYTNQFNQ--TALAR-------AQELFEATPQTNRRQTHAAIQD 548
            ..|.||       .:.:.|.|:...:.||  |.|.|       |.:|..:.  .|.:::.:||.|
Worm   452 NSEELEIWLRESQSVPEEILSVIVEKLNQETTTLLRKKVQDIQAHQLVASV--ANSKKSLSAIGD 514

  Fly   549 RINTLLIDIRLYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKNTN-LNVDQ 612
            :...|......:|.....|.....:.|.:||||::||||...|..||     :.|.|.: |...|
Worm   515 KCRQLYDSFNTFETATSTFADPLGSDLRQYLLKTVGNEIALALLSYV-----MGVDNAHQLKEKQ 574

  Fly   613 RNKLAQECEAQYRAALLEQNKALNKSIDDFELATETVLKTC------SMIIKKVDKKKDRLLIAD 671
            |.:..:......|..:.....:|..:.||........:..|      |:.:||||||....:.|.
Worm   575 REETIENLPEMLRDPIRSVFASLKSTDDDALDKFHDAVYNCSAPSATSLALKKVDKKGRAEVGAK 639

  Fly   672 HKKKLQKQLLECNEPALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYH 736
            ...:|.:||....|||..|.|:.|.:... .|....|||||||.::..|:....|:
Worm   640 ITAELHEQLCSQTEPATTLLLSVLYILAK-AGRPTTASGKFVSQLVAQIKDLCPEN--------- 694

  Fly   737 DLVLQVLQA 745
              |..:|||
Worm   695 --VFDLLQA 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	73/269 (27%)
ufl-1	NP_501090.1	DUF2042	6..273	CDD:286786	73/269 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167351
Domainoid	1	1.000	139	1.000	Domainoid score	I2977
eggNOG	1	0.900	-	-		E1_KOG2235
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I2490
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55411
OrthoDB	1	1.010	-	-		D244863at33208
OrthoFinder	1	1.000	-	-		FOG0006174
OrthoInspector	1	1.000	-	-		oto17681
orthoMCL	1	0.900	-	-		OOG6_103555
Panther	1	1.100	-	-	LDO	PTHR31057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2878
SonicParanoid	1	1.000	-	-		X5107
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.840