DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1965 and PAXBP1

DIOPT Version :9

Sequence 1:	NP_649689.1	Gene:	CG1965 / 40842	FlyBaseID:	FBgn0037466	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_057715.2	Gene:	PAXBP1 / 94104	HGNCID:	13579	Length:	917	Species:	Homo sapiens

Alignment Length:	995	Identity:	306/995 - (30%)
Similarity:	474/995 - (47%)	Gaps:	195/995 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFRKPKKIQRRVFSSNADEEEDGASLDPDAEMEAPP--PPIISGKREKE---------------- 49
            :|||.:::..|  ..|..|||:   .:.|.|.|.||  ||..:|:....
Human     1 MFRKARRVNVR--KRNDSEEEE---RERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPG 60

  Fly    50 -----------------------------KSRKAIKPQEDNSKPKA-LLSFADDEDDG-EVFQVR 83
                                         |.||  :|:|:...|:| ||||.|:|::. |||:|:
Human    61 PSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRK--RPRENKEVPRASLLSFQDEEEENEEVFKVK 123

  Fly    84 KSSHSKKVMRMLDKERRKKKREERAENSGHPGGENGSTQHLESSGGPSSGPPNSNSNPANAGRYK 148
            |||:|||::::|.||.::...:.:.:...:...|  |.|.|:.:|
Human   124 KSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAE--SEQPLDKTG-------------------- 166

  Fly   149 SASDQSKSKKSDNHMIQTEIRTDDFVLVVKKSETPEAILNGRAALCAGREDMSDEEDQQSE-DGG 212
                         |:..|  ..:|.|::.:..|                    ||.|.:|| :..
Human   167 -------------HVKDT--NQEDGVIISEHGE--------------------DEMDMESEKEEE 196

  Fly   213 HDKTRHRFSKPEHLKQMLESGSIPDAAMIHAARKRRQRAREQGAGDYIPIEEPKEPAKLSNRLPC 277
            ..||...||.......:|..|.|||||.||||||:||.|||  .||:.|  ...||.|  .||..
Human   197 KPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARE--LGDFTP--HDNEPGK--GRLVR 255

  Fly   278 E---DVEGDQSDDEERMDMNDITGRKEREERREQFYAVENDSTD----GDSDREMNEWENQQIRK 335
            |   |...|:.|||:|..:..:..:.:|::..|:. .:|....|    |:.|.|::.||.:||||
Human   256 EDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEI-GIEGSDDDALVTGEQDEELSRWEQEQIRK 319

  Fly   336 GVTAAQLVHSQHETV----LSRFMIKPAPSGIG-----TGMDDGDSTAAQSTSTLLEQAYAKNAL 391
            |:...|:..||...|    .:.:...|..|..|     |.....|:.:.::.:|:   .:...:.
Human   320 GINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTV---PFKTPSN 381

  Fly   392 ERTNLAA-AVRSSVKTKKEKAKATALRTPQEILAAIQSRLSELKERSADHSASMARISTELKALK 455
            |.|.:.. .|:..:|.:.:..|.......|:....:|||:        |.:.::.|:
Human   382 EMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRV--------DSTRAIERL-------- 430

  Fly   456 LQQLECQQNAPTAAAKYKFYQEIKCYVNDLVDCLSEKAPVIYDLEKRALQQYGKNQRYLVNRRRQ 520
                  :.::.....:|||.||::.||.||::|.|||.|:|.:||....|.|.:....||.||:.
Human   431 ------EGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQD 489

  Fly   521 DVRDQAKEI-AESAKPITAAS-----RRTPDYEEQV-RRAAEREGRRTRRRCERERNDLLSSHLD 578
            |::|::.|. :.|.|.:.|.:     |....|:|.. ||.||||.||||||..||:...::.||:
Human   490 DIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLE 554

  Fly   579 GMSSDDEIADQQQELSVTTM----AQIESQSVDALEDVTDDFSKIELILMKFFAWRKTDMSSYQD 639
            |:|||||    :....:|..    .:|..:|....|||.:.|..|:.|..:|.|||....:||:|
Human   555 GLSSDDE----ETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKD 615

  Fly   640 AFVSLCLPKVLAPLVRHELVLWSPLLDVYADIENMRWYQACMLYASQADETVEQLKIDPDINLVP 704
            |::.|||||:..||:|.:|:.|:||.....|.|||.|:::.:.|..   |..||.|.|.|:.|:|
Human   616 AYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGC---EEREQEKDDVDVALLP 677

  Fly   705 ALIEKIVLPKVTALVTECWDPLSTTQTLRLVGFINRLGREFP--LSGTNKQLNKLFESIMERMRL 767
            .::||::|||:|.:....|||.|||||.|:||...:|...:|  ::..||......::::.|||.
Human   678 TIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRR 742

  Fly   768 ALENDVFIPIFPKQVQEAKTS----FFQRQFCSGLKLFRNFLSWQGILADKLLRELAIGALLNRY 828
            .|::|||:|::||.|.|.|.|    ||||||.|.:||..|||.|.||.::|.|:||:|..|||||
Human   743 TLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRY 807

  Fly   829 LLLAMRVCT-PNDAINKAYIIVNTLPTVWL--LPNSETLKNMELFIGYIKQTLE-----NCDASN 885
            :|:|.:... .:|:|.||..::|..|..|.  |....|:..:|.|..|:....:     :...|:
Human   808 ILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSD 872

  Fly   886 PIFMQSSDKAKQILQRLHSL 905
            .....:.:..|||::.|.|:
Human   873 VEKRNARENIKQIVKLLASV 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1965	NP_649689.1	GCFC	619..829	CDD:285127	95/215 (44%)
PAXBP1	NP_057715.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..123		32/128 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..205		17/118 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..275		22/51 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..381		2/21 (10%)
		Necessary and sufficient for interaction with PAX7. /evidence=ECO:0000250	378..558		60/201 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..564		20/37 (54%)
		GCFC	595..806	CDD:285127	93/213 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159710
Domainoid	1	1.000	187	1.000	Domainoid score	I3342
eggNOG	1	0.900	-	-		E1_KOG2136
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9604
Inparanoid	1	1.050	389	1.000	Inparanoid score	I2018
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52604
OrthoDB	1	1.010	-	-		D1217358at2759
OrthoFinder	1	1.000	-	-		FOG0002728
OrthoInspector	1	1.000	-	-		otm40661
orthoMCL	1	0.900	-	-		OOG6_104438
Panther	1	1.100	-	-	O	PTHR12214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3147
SonicParanoid	1	1.000	-	-		X2522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800