DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1965 and GCFC2

DIOPT Version :9

Sequence 1:	NP_649689.1	Gene:	CG1965 / 40842	FlyBaseID:	FBgn0037466	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_005264577.1	Gene:	GCFC2 / 6936	HGNCID:	1317	Length:	789	Species:	Homo sapiens

Alignment Length:	857	Identity:	245/857 - (28%)
Similarity:	376/857 - (43%)	Gaps:	143/857 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 RRKKKREERAENSGHPGG------ENGSTQHLESSGGPSSGPPNSNSNPANAG---RYKSASDQS 154
            |.|:...:||.:|....|      |.|:.:.|...|.....||:.......||   |.:....:.
Human     4 RPKRTFRQRAADSSDSDGAEESPAEPGAPRELPVPGSAEEEPPSGGGRAQVAGLPHRVRGPRGRG 68

  Fly   155 KSKKSDNHMIQTEIRTDDFVLVVKKSETPEAILNGRAALCAGRE----DMS-DEED------QQS 208
            :...|.....:...|.|:                       |.|    |:| ||||      :..
Human    69 RVWASSRRATKAAPRADE-----------------------GSESRTLDVSTDEEDKIHHSSESK 110

  Fly   209 EDGGHDKTRHRFSKPEHLKQMLESG-----SIPDAAMIHAARKRRQRAREQGAGDYIPIEEPKEP 268
            :|.|...........:.|...:.|.     .|||||.|.|||::|:.||.|  .|||.::.....
Human   111 DDQGLSSDSSSSLGEKELSSTVSSSLFPSVKIPDAAFIQAARRKRELARAQ--DDYISLDVQHTS 173

  Fly   269 AKLSNRLPCEDVEGDQSDDEER---MDMNDITGRKEREERREQFYAVENDSTDGDSDREMNEWEN 330
            :....:...||....:.||.|:   ..:...|.|:...|  |.....|..|.:...|.:.:.||.
Human   174 SISGMKRESEDDPESEPDDHEKRIPFTLRPQTLRQRMAE--ESISRNEETSEESQEDEKQDTWEQ 236

  Fly   331 QQIRKGVTAAQLVHSQHETVLSRFMIKPAPSGIGTGMDDGDSTAAQSTSTLLEQAYAKNALERTN 395
            ||:||.|.    :..:.:..||          .|.|
Human   237 QQMRKAVK----IIEERDIDLS----------CGNG----------------------------- 258

  Fly   396 LAAAVRSSVKTKKEKAKATALRTP----QEILAAIQSRLSELKERSADHSASMARISTELKALK- 455
                   |.|.||..   |::..|    :.|...:.:||:.|:|....|.....:...::|:.|
Human   259 -------SSKVKKFD---TSISFPPVNLEIIKKQLNTRLTLLQETHRSHLREYEKYVQDVKSSKS 313

  Fly   456 -LQQLECQQNAPTAAAKYKFYQEIKCYVNDLVDCLSEKAPVIYDLEKRALQQYGKNQRYLVNRRR 519
             :|.||...|   .|...|||:.:|.||.:|:|||:||...|.::|........|.....:.||:
Human   314 TIQNLESSSN---QALNCKFYKSMKIYVENLIDCLNEKIINIQEIESSMHALLLKQAMTFMKRRQ 375

  Fly   520 QDVRDQAKEIAE-SAKPITAASRRTPDYEEQVRRAAEREGRRTRRRCERERNDLLS---SHLDGM 580
            .:::.::..:.: |.|..|:.|......|:......|.|.|||:||..|    :||   :|.:|.
Human   376 DELKHESTYLQQLSRKDETSTSGNFSVDEKTQWILEEIESRRTKRRQAR----VLSGNCNHQEGT 436

  Fly   581 SSDDEIADQQQELSVTTMAQIESQSVDALEDVTDDFSKIELILMKFFAWRKTDMSSYQDAFVSLC 645
            |||||:...:......:...|..:.....|:|.|||..|:.||:||..||:....||.:||:|||
Human   437 SSDDELPSAEMIDFQKSQGDILQKQKKVFEEVQDDFCNIQNILLKFQQWREKFPDSYYEAFISLC 501

  Fly   646 LPKVLAPLVRHELVLWSPLLDVYADIENMRWYQACMLYASQADETVEQLKID--PDINLVPALIE 708
            :||:|.||:|.:|:.|:||......::.|.|:::...:   .|.:||..|.:  .|..::.|:|.
Human   502 IPKLLNPLIRVQLIDWNPLKLESTGLKEMPWFKSVEEF---MDSSVEDSKKESSSDKKVLSAIIN 563

  Fly   709 KIVLPKVTALVTECWDPLSTTQTLRLVGFINRLGREFPL--SGTNKQLNKLFESIMERMRLALEN 771
            |.::|::|..|...||||||:||..|:.....:..|...  :..:|....|.:||:.||:.|:|:
Human   564 KTIIPRLTDFVEFLWDPLSTSQTTSLITHCRVILEEHSTCENEVSKSRQDLLKSIVSRMKKAVED 628

  Fly   772 DVFIPIFPKQVQEAKTS----FFQRQFCSGLKLFRNFLSWQGILADKLLRELAIGALLNRYLLLA 832
            |||||::||...|.|||    |.:|||.||||||||.|.|.|:|.|..|:||.:|.||||||::|
Human   629 DVFIPLYPKSAVENKTSPHSKFQERQFWSGLKLFRNILLWNGLLTDDTLQELGLGKLLNRYLIIA 693

  Fly   833 MRVCTPN-DAINKAYIIVNTLPTVWLLPNS---ETLKNMELFIGYIKQTLENCDASNPIFMQSSD 893
            :...||. |.:.|...:...||..| ..||   .::..:|.||.::.|:......|.  |....:
Human   694 LLNATPGPDVVKKCNQVAACLPEKW-FENSAMRTSIPQLENFIQFLLQSAHKLSRSE--FRDEVE 755

  Fly   894 KAKQILQRLHSL 905
            :...||.::.:|
Human   756 EIILILVKIKAL 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1965	NP_649689.1	GCFC	619..829	CDD:285127	91/217 (42%)
GCFC2	XP_005264577.1	NTR2	125..>243	CDD:292097	36/121 (30%)
GCFC2	XP_005264577.1	GCFC	475..690	CDD:285127	91/217 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2136
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52604
OrthoDB	1	1.010	-	-		D1217358at2759
OrthoFinder	1	1.000	-	-		FOG0002728
OrthoInspector	1	1.000	-	-		otm40661
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3147
SonicParanoid	1	1.000	-	-		X2522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850