DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1965 and Paxbp1

DIOPT Version :9

Sequence 1:	NP_649689.1	Gene:	CG1965 / 40842	FlyBaseID:	FBgn0037466	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_080386.3	Gene:	Paxbp1 / 67367	MGIID:	1914617	Length:	919	Species:	Mus musculus

Alignment Length:	1005	Identity:	314/1005 - (31%)
Similarity:	470/1005 - (46%)	Gaps:	213/1005 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFRKPKKIQRRVFSSNADEE-------EDGASLDPDAEME---------------------APPP 39
            :|||.:::..|..:.:.:||       |....|.|.|..|                     .|||
Mouse     1 MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPASGEEPGPGGGDRAPAGESLLGPGPLPPP 65

  Fly    40 PI-------------ISGKREKE---KSRKAIKPQEDNSKPKA-LLSFADDEDDG-EVFQVRKSS 86
            |.             |||..|..   |.||  :|:|:...|:| ||||.|:|::. |||:|:|||
Mouse    66 PSAHHPGLGAEAGGGISGGAEPGNGLKPRK--RPRENKEVPRASLLSFQDEEEENEEVFKVKKSS 128

  Fly    87 HSKKVMRMLDKERRKKKREERAENSGHPGGENGSTQHLESSGGPSSGPPNSNSNPANAGRYKSAS 151
            :|||::::|.||                                                ||  .
Mouse   129 YSKKIVKLLKKE------------------------------------------------YK--E 143

  Fly   152 DQSKSKKSDNHMIQTEIRT--DDFVLVVK----KSETPEAILNGRAALCAGREDM---SDEEDQQ 207
            |..|||      |:||:.|  |....:.|    |...||   :|......|.::|   |::|:::
Mouse   144 DLEKSK------IKTELNTAADSDQPLDKTCHAKDTNPE---DGVVISEHGEDEMDMESEKEEEK 199

  Fly   208 SEDGGHDKTRHRFSKPEHLKQMLESGSIPDAAMIHAARKRRQRAREQGAGDYIPIEEPKEPAKLS 272
            .:.||      .||.......:|..|.|||||.||||||:||.|||  .||:.|  ...||.|
Mouse   200 PKAGG------AFSNALSSLNVLRPGEIPDAAFIHAARKKRQLARE--LGDFTP--HDSEPGK-- 252

  Fly   273 NRLPCE---DVEGDQSDDEERMDMNDITGRKEREERREQFYAVENDSTD----GDSDREMNEWEN 330
            .||..|   |...|:.|||:|..:..:..:.:|::..|:. .:|....|    |:.|.|::.||.
Mouse   253 GRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEI-GIEGSDDDALVTGEQDEELSRWEQ 316

  Fly   331 QQIRKGVTAAQLVHSQHETVLSRFMIKPAPSGIGTGMDDGDSTAAQSTSTLLEQAYAKNALERTN 395
            :|||||:...|:..||             ||.:.....:...|.....|..:..:|
Mouse   317 EQIRKGINIPQVQASQ-------------PSEVNVYYQNTYQTMPYGASYGIPYSY--------- 359

  Fly   396 LAAAVRSSVKTKKEKAKATA-LRTPQEILAAI---------QSRLSELKERSADHSASMARISTE 450
               ....|...|.:|...|. .:||...:|.:         :.||..:||.   |..:..:....
Mouse   360 ---TAYGSSDAKSQKTDNTVPFKTPSNEMAPVTIDLVKRQLKDRLDSMKEL---HKTNQQQHEKH 418

  Fly   451 LKA-----LKLQQLECQQNAPTAAAKYKFYQEIKCYVNDLVDCLSEKAPVIYDLEKRALQQYGKN 510
            |::     ..:::||.....  ...:|||.||::.||.||::|.|||.|:|.:||....|.|.:.
Mouse   419 LQSRVDSTRAIERLEGSSGG--IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQR 481

  Fly   511 QRYLVNRRRQDVRDQAKEI-AESAKPITAAS-----RRTPDYEEQV-RRAAEREGRRTRRRCERE 568
            ...||.||:.|::|::.|. :.|.|.:.|.:     |....|:|.. ||.||||.||||||..||
Mouse   482 ASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQARE 546

  Fly   569 RNDLLSSHLDGMSSDDEIADQQQELSVTTM----AQIESQSVDALEDVTDDFSKIELILMKFFAW 629
            :...::.||:|:|||||    :....:|..    .:|..:|....|||.:.|..|:.|..:|.||
Mouse   547 QTGQMADHLEGLSSDDE----ETSTDITNFNLEKDRILKESSKVFEDVLESFYSIDCIKAQFEAW 607

  Fly   630 RKTDMSSYQDAFVSLCLPKVLAPLVRHELVLWSPLLDVYADIENMRWYQACMLYASQADETVEQL 694
            |.....||:||::.|||||:..||:|.:|:.|:||.....|.|.|.|:::.:.|..   |..||.
Mouse   608 RSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFETMLWFESLLFYGC---EDREQE 669

  Fly   695 KIDPDINLVPALIEKIVLPKVTALVTECWDPLSTTQTLRLVGFINRLGREFP--LSGTNKQLNKL 757
            |.:.|:.|:|.::||::|||:|.:....|||.|||||.|:||...:|...:|  ::..||.....
Mouse   670 KDEADVALLPTIVEKVILPKLTVIAETMWDPFSTTQTSRMVGITMKLINGYPSVVNADNKNTQVY 734

  Fly   758 FESIMERMRLALENDVFIPIFPKQVQEAKTS----FFQRQFCSGLKLFRNFLSWQGILADKLLRE 818
            .::::.|||..|::|||:|::||.|.|.|.|    ||||||.|.:||..|||.|.||.::|.|:|
Mouse   735 LKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQE 799

  Fly   819 LAIGALLNRYLLLAMRVCT-PNDAINKAYIIVNTLPTVWL--LPNSETLKNMELFIGYIKQTLE- 879
            |:|..|||||:|:|.:... .:|:|.||..::|..|..|.  |....|:..:|.|..|:....:
Mouse   800 LSIDGLLNRYILMAFQNSEYGDDSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADT 864

  Fly   880 ----NCDASNPIFMQSSDKAKQILQRLHSL 905
                :...|:.....:.:..|||::.|.|:
Mouse   865 IYRNSIGCSDVEKRNARENIKQIVKLLASV 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1965	NP_649689.1	GCFC	619..829	CDD:285127	93/215 (43%)
Paxbp1	NP_080386.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		32/120 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..206		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..277		18/45 (40%)
		Necessary and sufficient for interaction with PAX7. /evidence=ECO:0000269\|PubMed:22862948	380..560		60/184 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..566		19/36 (53%)
		GCFC	597..808	CDD:285127	91/213 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850081
Domainoid	1	1.000	183	1.000	Domainoid score	I3439
eggNOG	1	0.900	-	-		E1_KOG2136
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9604
Inparanoid	1	1.050	380	1.000	Inparanoid score	I2043
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52604
OrthoDB	1	1.010	-	-		D1217358at2759
OrthoFinder	1	1.000	-	-		FOG0002728
OrthoInspector	1	1.000	-	-		otm42735
orthoMCL	1	0.900	-	-		OOG6_104438
Panther	1	1.100	-	-	O	PTHR12214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2522
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770