DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1965 and Gcfc2

DIOPT Version :9

Sequence 1:	NP_649689.1	Gene:	CG1965 / 40842	FlyBaseID:	FBgn0037466	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_808552.2	Gene:	Gcfc2 / 330361	MGIID:	2141656	Length:	769	Species:	Mus musculus

Alignment Length:	847	Identity:	244/847 - (28%)
Similarity:	376/847 - (44%)	Gaps:	150/847 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 RKKKREERAENSGHPGGENGSTQHLESSGGPSSGP--PNSNSNPANAGRYKSASDQSKSKKSDNH 162
            |:::.|....:|...|.:..|.:...|:||.:.|.  |....:....||..::|.:|
Mouse    10 RRRQVESSDSDSDSDGAKEQSAEEPASAGGRTEGAERPRGARSARGRGRVWASSRRS-------- 66

  Fly   163 MIQTEIRTDDFVLVVKKSETPEAILNG-RAALCAGREDMSDEEDQQSEDGGHDKTRHRFSKPEHL 226
                                |.|...| ..|.|...|..:||     |:|.|..|.   ||.:..
Mouse    67 --------------------PGAAPRGDGGAECRTAELSTDE-----EEGTHTLTG---SKGDRS 103

  Fly   227 KQMLESGS-----------IPDAAMIHAARKRRQRAREQGAGDYIPIEE----PKEPAKLSNRLP 276
            .....|.|           |||||.|.|||::|:.||.  .||||.::.    .....|.||.
Mouse   104 PSSDSSCSLEERDVSPIVEIPDAAFIQAARRKRELART--PGDYISLDVNHSCSTSDCKRSNE-- 164

  Fly   277 CEDVEGDQSDDEERMDMNDITGRKEREERREQFYAVENDSTDGDSDREMNEWENQQIRKGVTAAQ 341
             ||.|.|..|.|:|:..........:....|.....|..|.:...|...:.||.||:||.|.
Mouse   165 -EDPESDPDDHEKRILFTPKPQTLRQRMAEETSIRSEESSEESQEDENQDIWEQQQMRKAVR--- 225

  Fly   342 LVHSQHETVLSRFMIKPAPSGIGTGMDDGDSTAAQSTSTLLEQAYAKNALERTNLAAAVRSSVKT 406
                             .|:|                             :.|:|:.:.:|....
Mouse   226 -----------------IPAG-----------------------------QNTDLSHSSKSQTLK 244

  Fly   407 KKEKAKATALRTP----QEILAAIQSRLSELKERSADHSASMARISTELKALK--LQQLECQQNA 465
            |.:    |::..|    :.|...:.:||:.|:|....|.....:...::|:.|  :|.||   :|
Mouse   245 KFD----TSISFPPVNLEIIKKQLNNRLTLLQESHRSHQREYEKYEQDIKSSKTAIQNLE---SA 302

  Fly   466 PTAAAKYKFYQEIKCYVNDLVDCLSEKAPVIYDLEKRALQQYGKNQRYLVNRRRQDVRDQAKEIA 530
            ...|..|:||:.:|.||.:::|||:||...|.:||........|....|:.||:.:::.::..:.
Mouse   303 SDHAQNYRFYRGMKSYVENIIDCLNEKIVSIVELESSMYTLLLKRSEALLKRRQDELKCESSYLQ 367

  Fly   531 E-SAKPITAASRRTPDYEEQVRRAAEREGRRTRRRCERERNDLLS---SHLDGMSSDDEIADQQQ 591
            : |.|..|:|:......|:..|...|.|.||.:||..||    ||   .|.:|||||||::..:.
Mouse   368 QLSRKDETSANGSLAVDEKDQRILEEIEARRMQRRQARE----LSGSCDHQEGMSSDDELSPAEM 428

  Fly   592 ELSVTTMAQIESQSVDALEDVTDDFSKIELILMKFFAWRKTDMSSYQDAFVSLCLPKVLAPLVRH 656
            .........|........|||.|||..::.||:||..||:....||.:|||..||||:|:||:|.
Mouse   429 TNFHKCQGDILQDCKKVFEDVHDDFCNVQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRV 493

  Fly   657 ELVLWSPLLDVYADIENMRWYQACMLYASQADETVEQLKIDPDINLVPALIEKIVLPKVTALVTE 721
            :|:.|:||......::.|.|:.|...:...:.:.:.: :...|..::.|:|.|.|:|::|..|..
Mouse   494 QLLDWNPLKMDSIGLDKMPWFTAITEFMESSMDDIGK-EDGSDKKILAAVINKTVVPRLTDFVET 557

  Fly   722 CWDPLSTTQTLRL-----VGFINRLGREFPLSGTNKQLNKLFESIMERMRLALENDVFIPIFPKQ 781
            .||||||:||..|     |.| .:...|..:| .|||  .|.:||:.||:.::|:|:|||::||.
Mouse   558 IWDPLSTSQTRSLTVHCRVAF-EQFASENEVS-KNKQ--DLLKSIVARMKKSIEDDIFIPLYPKS 618

  Fly   782 VQEAKTS----FFQRQFCSGLKLFRNFLSWQGILADKLLRELAIGALLNRYLLLAMRVCTPN-DA 841
            .:|.|.|    |.:|||...||||||.|.|.|:|.|..|::|.:|.||||||::::....|. |.
Mouse   619 SEEGKMSPHSKFQERQFWGALKLFRNILLWNGLLPDDTLQDLGLGKLLNRYLIISLTNAVPGPDV 683

  Fly   842 INKAYIIVNTLPTVWLLPNS---ETLKNMELFIGYIKQTLENCDASNPIFMQSSDKAKQILQRLH 903
            :.|...|...||..| ..||   .::..:|.||.::.|:.:...:|.  |.....:...||.::.
Mouse   684 VKKCSQIAACLPERW-FENSAMRTSIPQLENFIKFLLQSAQKLSSSE--FRNEVSEIILILVKVK 745

  Fly   904 SL 905
            :|
Mouse   746 AL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1965	NP_649689.1	GCFC	619..829	CDD:285127	87/218 (40%)
Gcfc2	NP_808552.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..122		30/147 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..212		21/82 (26%)
		GCFC	456..670	CDD:285127	87/218 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2136
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52604
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002728
OrthoInspector	1	1.000	-	-		otm42735
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3147
SonicParanoid	1	1.000	-	-		X2522
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840