Protein Alignment CG1105 and ARRDC2

DIOPT Version :10

• Sequence 1: NP_649688.1
• Gene: CG1105 / 40841
• FlyBaseID: FBgn0037465
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_056498.1
• Gene: ARRDC2 / 27106
• HGNCID: 25225
• Length: 407
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 128/433 - (29%)
• Similarity: 201/433 - (46%)
• Gaps: 58/433 - (13%)

  Fly     3 LKGCELQLD------NPWNTYYAGQTVNGQVKFTFDSPKKVRGIIIRFLGEANTEWSEEKSVTTS 61
            :|...:|||      .|  .:..||.|.|:|.....|..:|..:.:|..|.|:..|:|.:|..:|
Human     6 VKAFSVQLDGATAGVEP--VFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRSAGSS 68

  Fly    62 EGKTE--NEVTQLKGHEEYFKIQYYLLGGKNSSETELPPGTHTYPFTCALPPNLPSSFEGEFGHV 124
            ...|:  :|..::..|      :..||.......|.||||.|.:.|:..|||.|.:||||:.|.|
Human    69 TAYTQSYSERVEVVSH------RATLLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSV 127

  Fly   125 RYTIKVTLDRPWKFDQDMKMAFTVIAPVDLNLNPRVKEPFKLELEKSFCCFCCRSGPLAVITNIP 189
            ||.||.||.|||...:..:..||||.|||:| .|.:..|.....||....:.|..|.:::...|.
Human   128 RYCIKATLHRPWVPARRARKVFTVIEPVDIN-TPALLAPQAGAREKVARSWYCNRGLVSLSAKID 191

  Fly   190 QTGFVSGQVLPITCEVDNTSNVNLTAVKFELRKLVTFHTNQPRSEKRESKVIIANLSVGPVNGGE 254
            :.|:..|:|:|:..|:||.|    |........:|...|...|..:::.:.::|:|:..||..|:
Human   192 RKGYTPGEVIPVFAEIDNGS----TRPVLPRAAVVQTQTFMARGARKQKRAVVASLAGEPVGPGQ 252

  Fly   255 SRTFT-QQMEIPALPPTNLLNCGIIALDYDLHVECEVSGPHRNLTGKVPITLGTIPLAGVRPPTQ 318
            ...:. :.:.||.:.| ::|:|.::.:||.|.|..::.|..:.|. ::|:.:|||||   .|
Human   253 RALWQGRALRIPPVGP-SILHCRVLHVDYALKVCVDIPGTSKLLL-ELPLVIGTIPL---HP--- 309

  Fly   319 FTDAPSAVQSEDPSLAPTQ----PVSPASPPGGDGVGGALGWNVADSTG---GGSLYP------- 369
            |....|:|.|....|...:    |..|.:||....|       |||:..   |.|.:|
Human   310 FGSRSSSVGSHASFLLDWRLGALPERPEAPPEYSEV-------VADTEEAALGQSPFPLPQDPDM 367

  Fly   370 NIPPPQFV---ETQYRAPTIAGRDDSEHTQMIGDGAFAPRYPT 409
            ::..|.|.   |.:||.|.:...:|.  ..::||  ..||..|
Human   368 SLEGPFFAYIQEFRYRPPPLYSEEDP--NPLLGD--MRPRCMT 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1105	NP_649688.1	Arrestin_N	6..155	CDD:425619	56/156 (36%)
		Arrestin_C	178..310	CDD:214976	34/132 (26%)
ARRDC2	NP_056498.1	Arrestin_N	9..158	CDD:425619	56/156 (36%)
		Arrestin_C	181..307	CDD:214976	34/131 (26%)