Protein Alignment CG1105 and TXNIP

DIOPT Version :10

• Sequence 1: NP_649688.1
• Gene: CG1105 / 40841
• FlyBaseID: FBgn0037465
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_006463.3
• Gene: TXNIP / 10628
• HGNCID: 16952
• Length: 391
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 99/432 - (22%)
• Similarity: 167/432 - (38%)
• Gaps: 78/432 - (18%)

  Fly     3 LKGCELQLDNPWNTYYAGQTVNGQVKFTFDSPKKVRGIIIRFLGEANTEWSEEKSVTTSEGKTEN 67
            :|..|:..::|...|.:|:.|.|:|........:|:.:.|...|.|...|.:...
Human     7 IKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQ---------- 61

  Fly    68 EVTQLKGHEEYFKIQYYLL-----GGKNSSETELPPGTHTYPFTCALPPN-LPSSFEGEFGHVRY 126
               |.|...||.:.:..||     .|:|......|...:.|.|...||.. |.:||:|::|.|.|
Human    62 ---QCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDY 123

  Fly   127 TIKVTLDRPWKFDQDMKMAFTVIAPVDLNLNPRVKEPFKLELEKSFCCFCCRSGPLAVITNIPQT 191
            .:|..||||.:..|:.|..|.|:..||:| .|.:..|...:.||...|.....|.::|...|.:.
Human   124 WVKAFLDRPSQPTQETKKNFEVVDLVDVN-TPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRK 187

  Fly   192 GFVSGQVLPITCEVDNTSNVNLTAVKFELRKLVTFHTNQPRSEKRESKVIIANLSVGPVNGGESR 256
            ||..|..:.|..:.:||    .:.:......:|..||.....   ::||:...||  .|.|....
Human   188 GFCEGDEISIHADFENT----CSRIVVPKAAIVARHTYLANG---QTKVLTQKLS--SVRGNHII 243

  Fly   257 TFT------QQMEIPALPPTNLLNCGIIALDYDLHVECEVSGPHRNLTGKVPITLGTIPLAGVRP 315
            :.|      :.:.:..:.| ::|.|.|:.::|.|.:...|.|..:.:. .:|:.:|
Human   244 SGTCASWRGKSLRVQKIRP-SILGCNILRVEYSLLIYVSVPGSKKVIL-DLPLVIG--------- 297

  Fly   316 PTQFTDAPSAVQSEDPSLAPTQPVSPASPPGGDGVGGALGW---NVADSTGGGSLYPNIPPPQFV 377
                  :.|.:.|...|:|             ......:.|   |:.|:......|.::.|.
Human   298 ------SRSGLSSRTSSMA-------------SRTSSEMSWVDLNIPDTPEAPPCYMDVIPE--- 340

  Fly   378 ETQYRAPTIAGRDDSEHTQMIGDGAFAPRYPTFQFNNATAPP 419
            :.:..:||....||.:.:|   |.......|.|:|    .||
Human   341 DHRLESPTTPLLDDMDGSQ---DSPIFMYAPEFKF----MPP 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1105	NP_649688.1	Arrestin_N	6..155	CDD:425619	43/154 (28%)
		Arrestin_C	178..310	CDD:214976	29/137 (21%)
TXNIP	NP_006463.3	Arrestin_N	10..152	CDD:451447	43/154 (28%)
		Arrestin_C	174..298	CDD:460676	29/149 (19%)