DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sodh-1 and Sord

DIOPT Version :9

Sequence 1:	NP_001287203.1	Gene:	Sodh-1 / 40836	FlyBaseID:	FBgn0024289	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_666238.1	Gene:	Sord / 20322	MGIID:	98266	Length:	357	Species:	Mus musculus

Alignment Length:	352	Identity:	202/352 - (57%)
Similarity:	271/352 - (76%)	Gaps:	3/352 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DNLTAVLHGIEDMRLEQRPIPEIADDEVLLAMDSVGICGSDVHYLAHGRIGDFVLTKPMIIGHES 68
            :||:.|:||..|:|||..||||:..::|||.|.|||||||||||..||||||||:.|||::|||:
Mouse     8 ENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEA 72

  Fly    69 AGVVAKLGKKVTTLKVGDRVAIEPGVPCRKCDHCKQGKYNLCPGMVFCATPPYDGNLTRYYKHAA 133
            ||.|.|:|:.|..||.|||||||||||....::||.|:|||.|.:.||||||.||||.|:|||.|
Mouse    73 AGTVTKVGELVKHLKPGDRVAIEPGVPREVDEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNA 137

  Fly   134 DFCFKLPDHVTMEEGALLEPLSVGVHACKRAEVTLGSKVLILGAGPIGLVTLMAAQAMGASEILI 198
            |||:||||.||.|||||:||||||::||:|..|:||:|||:.||||:|:|||:.|:||||:::::
Mouse   138 DFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVV 202

  Fly   199 TDLVQQRLDVAKELGATHTLLLKRDQTAEETAVLVQKTMGGQPDKSIDCCGAESSARLAIFATRS 263
            |||...||..|||:||..|:.:.: :|.:|.|..|:..:|.:|:.:|:|.|||||.:..|:||.|
Mouse   203 TDLSASRLTKAKEVGADFTIQVGK-ETPQEIASKVESLLGSKPEVTIECTGAESSVQTGIYATHS 266

  Fly   264 GGIVVVVGMGAAEIKLPLINALAREVDIRGVFRYCNDYAAALALVASGKVNVKRLVTHHFDIKET 328
            ||.:|:|||||..:.|||::|..|||||:|||||||.:..|::::||..:|||.||||.|.:::.
Mouse   267 GGTLVIVGMGAEMVNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVKPLVTHRFPLEKA 331

  Fly   329 AKAFETSRKGLGGAIKVMIHVQPRDTN 355
            .:||||::||:|  :||||...|.|.|
Mouse   332 VEAFETAKKGVG--LKVMIKCDPNDQN 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sodh-1	NP_001287203.1	PLN02702	4..346	CDD:215378	196/341 (57%)
Sodh-1	NP_001287203.1	sorbitol_DH	8..349	CDD:176188	197/340 (58%)
Sord	NP_666238.1	sorbitol_DH	11..350	CDD:176188	197/341 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834937
Domainoid	1	1.000	161	1.000	Domainoid score	I3996
eggNOG	1	0.900	-	-		E1_COG1063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56080
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1777
Isobase	1	0.950	-	0	Normalized mean entropy	S593
OMA	1	1.010	-	-		QHG56613
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001480
OrthoInspector	1	1.000	-	-		otm43959
orthoMCL	1	0.900	-	-		OOG6_100349
Panther	1	1.100	-	-	O	PTHR43161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R311
SonicParanoid	1	1.000	-	-		X751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740