Protein Alignment Antp and NKX6-2

DIOPT Version :10

• Sequence 1: NP_996167.1
• Gene: Antp / 40835
• FlyBaseID: FBgn0260642
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 63/264 - (23%)
• Similarity: 96/264 - (36%)
• Gaps: 116/264 - (43%)

  Fly   167 AVGGLGMVPEGGSPPLVDQMSGHHMNAQMTL--PHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMG 229
            |:||||                    ||:.|  ||              |:.|:         :|
Human    44 ALGGLG--------------------AQLPLGTPH--------------GISDI---------LG 65

  Fly   230 MYQQQSGVPPVGAPPQGMMHQGQGPPQMH-----------------QGHPGQHTPPSQNPNSQSS 277
            .        ||||...|::   .|.|:::                 :|:|        .|.::..
Human    66 R--------PVGAAGGGLL---GGLPRLNGLASSAGVYFGPAAAVARGYP--------KPLAELP 111

  Fly   278 GMPSPLY--------PWMRSQFG----------KCQERKRGRQTYTRYQTLELEKEFHFNRYLTR 324
            |.| |::        ||...:..          |..::|..|.|::..|...|||.|...:||..
Human   112 GRP-PIFWPGVVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAG 175

  Fly   325 RRRIEIAHALCLTERQIKIWFQNRRMKWKKEN-------KTKGEPGS-----GG----EGDEITP 373
            ..|..:|::|.:||.|:|:||||||.||:|.:       |.|.:..:     ||    :.||...
Human   176 PERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDDDEYNR 240

  Fly   374 PNSP 377
            |..|
Human   241 PLDP 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	32/175 (18%)
		Homeodomain	298..354	CDD:459649	25/55 (45%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		8/61 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		3/22 (14%)
		Homeodomain	147..205	CDD:459649	25/57 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		8/35 (23%)