Protein Alignment Antp and NKX2-1

DIOPT Version :10

• Sequence 1: NP_996167.1
• Gene: Antp / 40835
• FlyBaseID: FBgn0260642
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 64/245 - (26%)
• Similarity: 89/245 - (36%)
• Gaps: 62/245 - (25%)

  Fly   169 GGLGMVP-----EGGSPPLVDQMS----GHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQN 224
            |||| .|     :|.:.|....|.    |||  ..:|..:||         |..|||.::.....
Human    62 GGLG-APLAAYRQGQAAPPTAAMQQHAVGHH--GAVTAAYHM---------TAAGVPQLSHSAVG 114

  Fly   225 HHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGM---------- 279
            .:..|.....|.:||.    |..|......|..:..:|....|........:|||
Human   115 GYCNGNLGNMSELPPY----QDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGS 175

  Fly   280 ---------PSPLYPWMRSQFGKCQERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALC 335
                     |.|..|           |::.|..:::.|..|||:.|...:||:...|..:|..:.
Human   176 LGDVSKNMAPLPSAP-----------RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIH 229

  Fly   336 LTERQIKIWFQNRRMKWKKENKTKG-------EPGSGGEGDEITPPNSPQ 378
            ||..|:||||||.|.|.|::.|.|.       :.|.||.|.....|...|
Human   230 LTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQ 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	35/164 (21%)
		Homeodomain	298..354	CDD:459649	21/55 (38%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	21/55 (38%)