Protein Alignment Antp and NKX2-4

DIOPT Version :10

• Sequence 1: NP_996167.1
• Gene: Antp / 40835
• FlyBaseID: FBgn0260642
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 251
• Identity: 60/251 - (23%)
• Similarity: 79/251 - (31%)
• Gaps: 104/251 - (41%)

  Fly   231 YQQQSGV---------PPVG------APPQGMMHQ-----GQGPPQMHQGHPG------------ 263
            |::.||.         .|:|      |||.|...|     |..|.....||..
Human    24 YKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPSHAMAGHNAAAAAAAAAAAAA 88

  Fly   264 ----QHTPP--SQNPN------------------SQSSGM------------PSPLY-------- 284
                .|.||  ||.|:                  :.:.||            |.|.|
Human    89 AAATYHMPPGVSQFPHGAMGSYCNGGLGNMGELPAYTDGMRGGAATGWYGANPDPRYSSISRFMG 153

  Fly   285 ------------------------PWMRSQFGKCQERKRGRQTYTRYQTLELEKEFHFNRYLTRR 325
                                    |...:.......||| |..:::.|..|||:.|...:||:..
Human   154 PSAGVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKR-RVLFSQAQVYELERRFKQQKYLSAP 217

  Fly   326 RRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGE---PGSGGEGDEITPPNSPQ 378
            .|..:|..:.||..|:||||||.|.|.|::.|.|..   ...||.|....||.||:
Human   218 EREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPSPR 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	30/174 (17%)
		Homeodomain	298..354	CDD:459649	23/55 (42%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	24/56 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		9/28 (32%)