DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Antp and POU3F2

DIOPT Version :9

Sequence 1:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_005595.2	Gene:	POU3F2 / 5454	HGNCID:	9215	Length:	443	Species:	Homo sapiens

Alignment Length:	390	Identity:	95/390 - (24%)
Similarity:	131/390 - (33%)	Gaps:	153/390 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RPD-SPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQPSQNQQQQQAQQAPQQLQQQLPQVTQQVTH 148
            :|| .||.    |:.|.....:|..|...|||.||..|.|||||.||..||.||:.|.:   |.|
Human   100 QPDIKPSV----VVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHL---VHH 157

  Fly   149 PQQQQQQPVVYASC--------KLQAAVGGL----------GMVPEGGSPPLVDQMSGHHMNAQM 195
            .......|..:.|.        .:.|:.|||          ||:..||.|.   .:..|.:....
Human   158 AANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPA---GLHHHGLRDAH 219

  Fly   196 TLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQG 260
            ..|||..|                  |.:.|: ..:||    ||...||       ||||    |
Human   220 DEPHHADH------------------HPHPHS-HPHQQ----PPPPPPP-------QGPP----G 250

  Fly   261 HPGQHTPPSQNPNSQSSGMPSPLYPWMRSQFGKCQERKR----------------------GRQT 303
            |||.|..|..:.::.:|.        ...||.|..:::|                      .:.|
Human   251 HPGAHHDPHSDEDTPTSD--------DLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTT 307

  Fly   304 YTRYQTLEL-----------------------------EKEFHFNRYLTRRRRIEI--------- 330
            ..|::.|:|                             :|.....|...:|..||:
Human   308 ICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESH 372

  Fly   331 ---------------AHALCLTERQIKIWFQNRRMKWKKENKTKGE-PGS----GGEGDEITPPN 375
                           |.:|.|.:..:::||.|||.|.|:.....|. ||:    ||..|  |||:
Human   373 FLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRD--TPPH 435

Fly 376 375
Human 436 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	39/184 (21%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	18/105 (17%)
POU3F2	NP_005595.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..171		29/77 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..267		26/102 (25%)
		POU	262..336	CDD:197673	9/81 (11%)
		Homeobox	357..411	CDD:395001	12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..443		10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030