Protein Alignment Antp and PDX1

DIOPT Version :9

• Sequence 1: NP_996167.1
• Gene: Antp / 40835
• FlyBaseID: FBgn0260642
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 90/302 - (29%)
• Similarity: 114/302 - (37%)
• Gaps: 122/302 - (40%)

  Fly   136 QQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAV---------------GGLGMVPEGGS------ 179
            ::|....||....|...|:.|....|....|.:               |.||.:.:|..
Human     4 EEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPY 68

  Fly   180 --PPLVDQMS----GHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVP 238
              |||.|..:    .||:.||:.|||                                      |
Human    69 EVPPLADDPAVAHLHHHLPAQLALPH--------------------------------------P 95

  Fly   239 PVGAPPQGMMHQGQGPPQMHQGHPGQHTPPS--QNPNSQSSGMPSPLYPWMRS------------ 289
            |.|..|:|             ..||....|:  |.|           :|||:|
Human    96 PAGPFPEG-------------AEPGVLEEPNRVQLP-----------FPWMKSTKAHAWKGQWAG 136

  Fly   290 --QFGKCQERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKW 352
              ...:.:|.||.|..|||.|.|||||||.||:|::|.||:|:|..|.||||.||||||||||||
Human   137 GAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKW 201

  Fly   353 KK-ENKTKG---EPGSGG-----------EGDEI--TPPNSP 377
            || |:|.:|   ..|.||           .|:|:  .||..|
Human   202 KKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPP 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	36/187 (19%)
		Homeobox	301..354	CDD:395001	37/52 (71%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		10/59 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		5/36 (14%)
		Antp-type hexapeptide	118..123		3/15 (20%)
		Homeobox	149..202	CDD:278475	36/52 (69%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		14/43 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810