DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Antp and HOXD1

DIOPT Version :9

Sequence 1:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_078777.1	Gene:	HOXD1 / 3231	HGNCID:	5132	Length:	328	Species:	Homo sapiens

Alignment Length:	244	Identity:	70/244 - (28%)
Similarity:	94/244 - (38%)	Gaps:	81/244 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 YASCKLQ----------AAVGG-----LGMVPEGGSPPLVDQMS---GHHMNAQMTLPHHMGHP- 204
            ||.|.|:          ||.||     ||..|....|.::.:.:   |.|::...:.....|..
Human    82 YAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSF 146

  Fly   205 --QAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGP-----PQMHQGHP 262
              ..|:.|...|.|                                    ||     .....|||
Human   147 LLSGQVDYAAFGEP------------------------------------GPFPACLKASADGHP 175

  Fly   263 GQHTPPSQNPN------SQSSGMPSPL--YPWMR-----------SQFGKCQERKRGRQTYTRYQ 308
            |.....|..|.      |.:||:|:..  :.||:           :::|........|..::..|
Human   176 GAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQ 240

  Fly   309 TLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENK 357
            ..|||||||||:||||.||||||:.|.|.:.|:||||||||||.||..:
Human   241 LTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKRER 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	33/189 (17%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	34/52 (65%)
HOXD1	NP_078777.1	Antp-type hexapeptide	204..209		1/4 (25%)
		Homeobox	233..285	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810