Protein Alignment Antp and HMX1

DIOPT Version :10

• Sequence 1: NP_996167.1
• Gene: Antp / 40835
• FlyBaseID: FBgn0260642
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 71/289 - (24%)
• Similarity: 114/289 - (39%)
• Gaps: 62/289 - (21%)

  Fly   102 TNGQLGVPQQQQQQQQQPSQNQQQQQAQQAPQQLQQQLPQVTQQVTHPQQQQQQPVVYASCKLQA 166
            |.|. |..:.:::....| :::..:||::...|.::||...|           .|...|..:...
Human    36 TQGD-GSREDEEEDDDDP-EDEDAEQARRRRLQRRRQLLAGT-----------GPGGEARARALL 87

  Fly   167 AVGGLGM---VPEGGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVT--EVHQNHH 226
            ..|.||:   .|.|..||......|          ....:|:|..||.....||.:  :..:...
Human    88 GPGALGLGPRPPPGPGPPFALGCGG----------AARWYPRAHGGYGGGLSPDTSDRDSPETGE 142

  Fly   227 NMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPN-SQSSGMPSPLYPWMRSQ 290
            .||..:        ||.|:|   .|.|..|..........|.:.... |:.:.:|:..
Human   143 EMGRAE--------GAWPRG---PGPGAVQREAAELAARGPAAGTEEASELAEVPAAA------- 189

  Fly   291 FGKCQ--------ERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQN 347
             |:.:        .:|:.|..::|.|..:||..|...|||:...|..:|.:|.|||.|:||||||
Human   190 -GETRGGVGVGGGRKKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQN 253

  Fly   348 RRMKWKKENKTKGEPGSGGEGDEITPPNS 376
            ||.|||::...:.|..|      ::||.:
Human   254 RRNKWKRQLAAELEAAS------LSPPGA 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	29/158 (18%)
		Homeodomain	298..354	CDD:459649	27/55 (49%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		39/208 (19%)
		Homeodomain	206..260	CDD:459649	26/53 (49%)
		HMX family specific domain 1	263..273		2/15 (13%)
		HMX family specific domain 2	276..289		0/1 (0%)