DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Antp and pou3f1

DIOPT Version :9

Sequence 1:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_571236.1	Gene:	pou3f1 / 30398	ZFINID:	ZDB-GENE-980526-372	Length:	368	Species:	Danio rerio

Alignment Length:	422	Identity:	77/422 - (18%)
Similarity:	116/422 - (27%)	Gaps:	184/422 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TNSYMGADMHHGHYPGNGVTDLDAQQM--HHYSQ----NANHQGNMPYPRFPPYDRMPYYNGQGM 74
            :|..|..|....|   .|.|..:.|:|  |.|.|    |..|..::.:.::.|.....:.:|..:
Zfish    16 SNPLMHPDSDRMH---QGTTYREVQKMMHHEYLQGLATNTGHPMSLTHHQWLPTSNTDWTSGTHI 77

  Fly    75 DQQQQHQ--VYSRPDSPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQPSQNQQQQQAQQAPQQLQQ 137
            .|.:.::  |.||.|                  ||....:.....||:||  ......||.....
Zfish    78 GQAEHNKASVQSRED------------------LGNGYHRSHLVHQPTQN--SHHGSWAPTTTHH 122

  Fly   138 QLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMG 202
            ..|      ..|.....|.:||:               :.|...|..|.|.||
Zfish   123 LSP------LSPASNGHQSLVYS---------------QTGYTMLSPQPSLHH------------ 154

  Fly   203 HPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTP 267
                       |:.|..     |.:.|.:..|             |...|.|...||.|..:..|
Zfish   155 -----------GLRDPL-----HDDAGSHDNQ-------------MESPQQPFSHHQDHSDEDAP 190

  Fly   268 PSQNPNSQSSGMPSPLYPWMRSQFGKCQERKR----------------------GRQTYTRYQTL 310
            .|.:                ..||.|..:::|                      .:.|..|::.|
Zfish   191 SSDD----------------LEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEAL 239

  Fly   311 ELE---------------KEFHFN--------------RYLTRRRRIEI---------------- 330
            :|.               :|...|              |...:|..||:
Zfish   240 QLSFKNMCKLKPLLNKWLEETDSNTGSPTNLDKIAAQGRKRKKRTSIEVGVKGALENHFLKCPKP 304

  Fly   331 -AH-------ALCLTERQIKIWFQNRRMKWKK 354
             ||       .|.|.:..:::||.|||.|.|:
Zfish   305 SAHEITTLAGTLQLEKEVVRVWFCNRRQKEKR 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	24/166 (14%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	20/105 (19%)
pou3f1	NP_571236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..134		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..193		16/86 (19%)
		POU	187..261	CDD:197673	11/89 (12%)
		Homeobox	282..335	CDD:278475	13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030