Protein Alignment Antp and NKX6-3

DIOPT Version :10

• Sequence 1: NP_996167.1
• Gene: Antp / 40835
• FlyBaseID: FBgn0260642
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_001351770.1
• Gene: NKX6-3 / 157848
• HGNCID: 26328
• Length: 265
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 68/241 - (28%)
• Similarity: 97/241 - (40%)
• Gaps: 53/241 - (21%)

  Fly   171 LGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQS 235
            |...||..:|  |.|.|..:...::: |..:| ||...| |..|:.|:........|..:.   |
Human    16 LAQFPEMKAP--VCQYSVQNSFYKLS-PPGLG-PQLAAG-TPHGITDILSRPVAAPNNSLL---S 72

  Fly   236 GVPPV----GAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPN------------SQSSGMPSPLY 284
            |.|.|    |...||:.:.    ||:.......:..|::..|            .|.|..|.||
Human    73 GYPHVAGFGGLSSQGVYYS----PQVGNFSKAGNEYPTRTRNCWADTGQDWRGGRQCSNTPDPL- 132

  Fly   285 PWMRSQFGKCQERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRR 349
                  .....::|..|.|:|.:|...|||.|...:||....|..:|::|.:||.|:|:||||||
Human   133 ------SDSIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRR 191

  Fly   350 MKWKKE------NKTKGEPGSGGEG------------DEITPPNSP 377
            .||:|:      :.|...||..|.|            ||...|..|
Human   192 TKWRKKSALEPSSSTPRAPGGAGAGAGGDRAPSENEDDEYNKPLDP 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	35/150 (23%)
		Homeodomain	298..354	CDD:459649	26/55 (47%)
NKX6-3	NP_001351770.1	Homeodomain	138..196	CDD:459649	26/57 (46%)