DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Antp and Hoxd3

DIOPT Version :9

Sequence 1:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	295	Identity:	89/295 - (30%)
Similarity:	119/295 - (40%)	Gaps:	82/295 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 QLQQQLPQVTQQ------------------------VTHPQQQQQQPVV-------YAS--CKLQ 165
            ||..:||:.|.|                        .:.|.|....|..       |.|  |.:|
Mouse     7 QLTLELPECTMQKAAYYENPGLFGGYGYSKATDTYGYSTPHQPYPPPAAANSLDSDYPSSACSIQ 71

  Fly   166 AAVGGLGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGM 230
            ::           :|.......|..:|.....| ..|:.|...|              .:...|:
Mouse    72 SS-----------APLRAPAHKGAELNGSCMRP-GTGNSQGGGG--------------GNQPPGL 110

  Fly   231 YQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGMPSPLYPWMRS--QFGK 293
            ..:|.  ||...||.........|.....|.|.:.|....:.:|.||.:...::|||:.  |..|
Mouse   111 NSEQQ--PPQPPPPPPPTLPPSSPTNPGSGVPAKKTKGGLSASSSSSTISKQIFPWMKESRQNSK 173

  Fly   294 -----------CQER-------KRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQ 340
                       |:::       ||.|..||..|.:||||||||||||.|.||:|:|:.|.|||||
Mouse   174 QKNSCATSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQ 238

  Fly   341 IKIWFQNRRMKWKKENKTKGEPGS-GGEGDEITPP 374
            |||||||||||:||:.|.||...| .|:..|.:||
Mouse   239 IKIWFQNRRMKYKKDQKAKGILHSPAGQSPERSPP 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	33/166 (20%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	38/52 (73%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		34/181 (19%)
		Antp-type hexapeptide	161..166		2/4 (50%)
		Homeobox	199..251	CDD:278475	38/51 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		6/16 (38%)
		DUF4074	370..431	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810