DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Antp and Hoxb3

DIOPT Version :9

Sequence 1:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus

Alignment Length:	288	Identity:	84/288 - (29%)
Similarity:	108/288 - (37%)	Gaps:	105/288 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QQVTHPQQQQQQPVVYASCKLQAAVGGLG-MVPEGGSPPLVDQMSGHHMN---AQMTLPHHMGHP 204
            |..||.:...|:    ::|.||:    || ..|...|    .:::|..|.   |...||...|.|
Mouse    38 QAATHLEGDYQR----SACSLQS----LGNAAPHAKS----KELNGSCMRPGLAPEPLPAPPGSP 90

  Fly   205 QAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPS 269
                                             ||..||.....:...|      |.|.:..||.
Mouse    91 ---------------------------------PPSAAPTSTTSNSNNG------GGPSKSGPPK 116

  Fly   270 QNPNSQSSGMPSPLYPWMRS--QFGKCQE------------------------------------ 296
            ....|.|: :...::|||:.  |..|.:.
Mouse   117 CGAGSNST-LTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGG 180

  Fly   297 ----------RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMK 351
                      .||.|..||..|.:||||||||||||.|.||:|:|:.|.|:||||||||||||||
Mouse   181 GDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMK 245

  Fly   352 WKKENKTKG-EPGSGGEGDEITPPNSPQ 378
            :||:.|.|| ...|||.....:||...|
Mouse   246 YKKDQKAKGLASSSGGPSPAGSPPQPMQ 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	34/196 (17%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	37/52 (71%)
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		18/103 (17%)
		Antp-type hexapeptide	129..134		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		4/58 (7%)
		Homeobox	195..248	CDD:365835	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		9/25 (36%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810