DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Antp and Hoxa3

DIOPT Version :9

Sequence 1:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_034582.1	Gene:	Hoxa3 / 15400	MGIID:	96175	Length:	443	Species:	Mus musculus

Alignment Length:	270	Identity:	91/270 - (33%)
Similarity:	113/270 - (41%)	Gaps:	83/270 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 GGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGV-----------PDVTEVHQNHHNM-- 228
            ||.|  ....:|...||... |:   .|.|.|| || ||           |.....|...|.:
Mouse    14 GGYP--YQAANGFAYNASQQ-PY---APSAALG-TD-GVEYHRPACSLQSPASAGGHPKTHELSE 70

  Fly   229 -------GMYQQQSGV--------PPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQ-NPNSQSS 277
                   |...|..|:        ||..|||  .....|.|||.....|....|||. :|...::
Mouse    71 ACLRTLSGPPSQPPGLGEPPLPPPPPQAAPP--APQPPQPPPQPPAPTPAAPPPPSSVSPPQSAN 133

  Fly   278 GMPSP-----------------LYPWMRSQFGKCQER----------------------KRGRQT 303
            ..|:|                 ::|||:......:::                      ||.|..
Mouse   134 SNPTPASTAKSPLLNSPTVGKQIFPWMKESRQNTKQKTSGSSSGESCAGDKSPPGQASSKRARTA 198

  Fly   304 YTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGE-PGSGGE 367
            ||..|.:||||||||||||.|.||:|:|:.|.||||||||||||||||:||:.|.||. ..|||:
Mouse   199 YTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQ 263

  Fly   368 GDEITPPNSP 377
                :|..||
Mouse   264 ----SPSRSP 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	44/196 (22%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	38/52 (73%)
Hoxa3	NP_034582.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..151		19/78 (24%)
		Antp-type hexapeptide	156..161		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..197		2/33 (6%)
		COG5576	<182..309	CDD:227863	51/92 (55%)
		Homeobox	196..249	CDD:365835	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..354		11/26 (42%)
		DUF4074	378..441	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810