Protein Alignment ftz and NKX2-1

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 53/216 - (24%)
• Similarity: 84/216 - (38%)
• Gaps: 24/216 - (11%)

  Fly   186 GDFATPPPTTPT-----SLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEE 245
            |:.:..||...|     |.|...|.:..|:.|........:..:|   ::...|.|..  ..:.:
Human   122 GNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMN---MSGMGGLGSL--GDVSK 181

  Fly   246 TLASDCKDSKRTRQT-YTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKS 309
            .:|......:|.|:. :::.|..|||:.|...:|::...|..:|:.:.|:..|:||||||.|.|.
Human   182 NMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKM 246

  Fly   310 K---KDRT----LDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSH 367
            |   ||:.    |.......|.|.....|..:.....:....:|||.:.......|..||
Human   247 KRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPA----- 306

  Fly   368 SHGYGLLNDYPQQQTHQQYDA 388
             .|...|..:.|||...|..|
Human   307 -PGAASLQGHAQQQAQHQAQA 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	12/66 (18%)
		Homeodomain	255..311	CDD:459649	21/59 (36%)
		KLF1_2_4_N	<321..404	CDD:425360	16/68 (24%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	20/55 (36%)