Protein Alignment ftz and NKX2-4

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 60/329 - (18%)
• Similarity: 95/329 - (28%)
• Gaps: 119/329 - (36%)

  Fly   161 TPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEIN 225
            :|..:......|:.||..:|.|..:|.....||.....|........||..|..::::....:.:
Human     4 SPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPS 68

  Fly   226 HR----------------------------IVTAPNGA--------------------------- 235
            |.                            :...|:||
Human    69 HAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGSYCNGGLGNMGELPAYTDGMRGGAA 133

  Fly   236 -------GDFNWSHIEETL------------------------------ASDCKDSKRTRQTYTR 263
                   .|..:|.|...:                              |:.....::.|..:::
Human   134 TGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKRRVLFSQ 198

  Fly   264 YQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSK---KDRTLDSSPEHCGAG 325
            .|..|||:.|...:|::...|..:|:.:.|:..|:||||||.|.|.|   ||:......:..|.|
Human   199 AQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLG 263

  Fly   326 YTAMLPP-----------------LEATSTATTG----APSVPVPMYHHHQTTAAYPAYSHSHSH 369
            .....||                 ....||.|.|    .|..|.|.....:.:.:.||.   |..
Human   264 PPPPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAGPQPPAPTPAPELEELSPSPPAL---HGP 325

  Fly   370 GYGL 373
            |.||
Human   326 GGGL 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	20/178 (11%)
		Homeodomain	255..311	CDD:459649	20/58 (34%)
		KLF1_2_4_N	<321..404	CDD:425360	17/74 (23%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	19/55 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		17/85 (20%)