Protein Alignment ftz and NKX1-1

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 178
• Identity: 60/178 - (33%)
• Similarity: 80/178 - (44%)
• Gaps: 28/178 - (15%)

  Fly   211 SPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHI------EETLASDCKDSK--RTRQTYTRYQTL 267
            :||.:.:|.|:|..... ..||.|||.......      .:...||.|..|  |.|..:|..|.:
Human   246 APGPRENSPVAQGPPGG-AAAPGGAGTTPQGTATAAKPKRKRTGSDSKSGKPRRARTAFTYEQLV 309

  Fly   268 ELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRT-LDSSPEHCGAGYTAMLP 331
            .||.:|...||::...|:::|.:|||:|.|:||||||||.|.||... .|:|....|.|...
Human   310 ALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTGGGGGPG--- 371

  Fly   332 PLEATSTATTG-----APSVPV--PMYHHHQTTAAYPAYSHSHSHGYG 372
            |.....|...|     :||.|:  |:..|  ..|.|||      ||.|
Human   372 PGAGPGTGLPGGLSPLSPSPPMGAPLGMH--GPAGYPA------HGPG 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	10/42 (24%)
		Homeodomain	255..311	CDD:459649	26/57 (46%)
		KLF1_2_4_N	<321..404	CDD:425360	17/59 (29%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		14/53 (26%)
		Homeodomain	297..353	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		13/49 (27%)