Protein Alignment ftz and PDX1

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 82/270 - (30%)
• Similarity: 110/270 - (40%)
• Gaps: 76/270 - (28%)

  Fly   128 YTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVD-YLDVYSPQSQTQ-------KLK 184
            |....|:.|.|....:   .|||.:          |||.... |:....|.....       .|:
Human     7 YYAATQLYKDPCAFQR---GPAPEF----------SASPPACLYMGRQPPPPPPHPFPGALGALE 58

  Fly   185 NGDFATPPPTTPTSLPPLE----------------GISTPPQSP-GEKSSSAVSQEINHRIVTAP 232
            .|   :||..:|..:|||.                .:..||..| .|.:...|.:|.|.  |..|
Human    59 QG---SPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNR--VQLP 118

  Fly   233 NGAGDFNW-----SHIEE------TLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRID 286
                 |.|     :|..:      ..|::.:::||||..|||.|.|||||||.||:||:|.||::
Human   119 -----FPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVE 178

  Fly   287 IANALSLSERQIKIWFQNRRMKSKKDRTLD------------SSPEH-C----GAGYTAMLPPLE 334
            :|..|:|:||.|||||||||||.||:....            :.||. |    |....|:.||..
Human   179 LAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPP 243

  Fly   335 ATSTATTGAP 344
            ........||
Human   244 PGGAVPPAAP 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	32/155 (21%)
		Homeodomain	255..311	CDD:459649	38/55 (69%)
		KLF1_2_4_N	<321..404	CDD:425360	7/29 (24%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		16/75 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		7/39 (18%)
		Antp-type hexapeptide	118..123		3/9 (33%)
		Homeodomain	147..203	CDD:459649	38/55 (69%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		11/53 (21%)