Protein Alignment ftz and NOTO

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001127934.1
• Gene: NOTO / 344022
• HGNCID: 31839
• Length: 251
• Species: Homo sapiens
• Alignment Length: 258
• Identity: 65/258 - (25%)
• Similarity: 96/258 - (37%)
• Gaps: 67/258 - (25%)

  Fly    75 PPVQPT---TPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKK 136
            ||..|:   ..||::.:..|......        |:|.||            |..|        :
Human    10 PPPAPSGSRVRPPRSGRSPAPRSPTG--------PNTPRA------------PGRF--------E 46

  Fly   137 APAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATP--PPTTPTS- 198
            :|.....:.|.|.|.         .|:||:......|:........|    .||.  |...|||
Human    47 SPFSVEAILARPDPC---------APAASQPSGSACVHPAFWTAASL----CATGGLPWACPTSW 98

  Fly   199 LP--------PLEGISTPPQSP--GEKSSSAVSQEINHRIVTAPNGAGDF-NWSHIEETLASDCK 252
            ||        |:.|   |..:|  |.........|:.|     .:|...| :|:..|: |....:
Human    99 LPAYLSVGFYPVPG---PRVAPVCGLLGFGVTGLELAH-----CSGLWAFPDWAPTED-LQDTER 154

  Fly   253 DSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTL 315
            ..||.|..:...|..||||.|.....:..::|..:|..|.|:|.|:::||||||:|.:|.:.|
Human   155 QQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQKL 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	40/189 (21%)
		Homeodomain	255..311	CDD:459649	22/55 (40%)
		KLF1_2_4_N	<321..404	CDD:425360
NOTO	NP_001127934.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		12/64 (19%)
		PHA03247	<16..120	CDD:223021	30/147 (20%)
		Homeodomain	157..213	CDD:459649	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..251