Protein Alignment ftz and HOXD12

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 70/285 - (24%)
• Similarity: 113/285 - (39%)
• Gaps: 75/285 - (26%)

  Fly    57 SESCYYYNNQEQVTTQ--TVPPVQ------PTTPPPKATKRKAEDDAASIIAAVEE--------- 104
            |...:|::|......|  .:||:.      |....| |:...|:...|:......:
Human    20 SPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATP-ASCAPAQPAGATAFGGFSQPYLAGSGPL 83

  Fly   105 --RPSTLRALLTNPVKKLK-YTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASE 166
              :|.|.:   ..|.::.| |.|:            .|...:......||:..|....|..:|.:
Human    84 GLQPPTAK---DGPEEQAKFYAPE------------AAAGPEERGRTRPSFAPESSLAPAVAALK 133

  Fly   167 DVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTA 231
            ...|                |:|.....||.|...|:|   .|.:||.|..:.....:|..:..|
Human   134 AAKY----------------DYAGVGRATPGSTTLLQG---APCAPGFKDDTKGPLNLNMTVQAA 179

  Fly   232 ----------PNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRID 286
                      |:|   ..|.      |:..: :::.|:.||:.|..|||.||..|.:|.|::|.:
Human   180 GVASCLRPSLPDG---LPWG------AAPGR-ARKKRKPYTKQQIAELENEFLVNEFINRQKRKE 234

  Fly   287 IANALSLSERQIKIWFQNRRMKSKK 311
            ::|.|:||::|:||||||||||.|:
Human   235 LSNRLNLSDQQVKIWFQNRRMKKKR 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	40/220 (18%)
		Homeodomain	255..311	CDD:459649	28/55 (51%)
		KLF1_2_4_N	<321..404	CDD:425360
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		4/31 (13%)
		Homeodomain	203..259	CDD:459649	28/55 (51%)