Protein Alignment ftz and HOXC4

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_055435.2
• Gene: HOXC4 / 3221
• HGNCID: 5126
• Length: 264
• Species: Homo sapiens
• Alignment Length: 893
• Identity: 146/893 - (16%)
• Similarity: 285/893 - (31%)
• Gaps: 298/893 - (33%)

  Fly    17 FALNHLGSTGEAAHTSSTFGSSVSGNGVANGGTHTSSGEWSNEIVSWLYSNFHKVPAPMDAWIKS 81
            :.:.:||        ..|.|.:::.:.||.|......|..:|.              |....:..
Human   109 YGMIYLG--------KDTNGENIAESLVAEGLATRREGMRANN--------------PEQNRLSE 151

  Fly    82 LNEAAKKVTSPTKCEVLFEGFGDHS--DV---LQPP---------KISNVRVEHGPRDHLTVRSN 132
            ..|.||    .:|..:..||.|.|:  |:   ::.|         |..|..:|| .||...||:.
Human   152 CEEQAK----ASKKGMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEH-VRDGSVVRAL 211

  Fly   133 V----HLPCVKL---------RLVSSQRTPERMIVSNYDVSIVDLRGEVECRMACIANQLYLMGC 184
            :    ||..|.|         |......|||..        ..:.:...|.|:.....|:.|..|
Human   212 LLPGHHLVTVMLSGIKCPTFRRETDGSETPEPF--------AAEAKFFTESRLLQRDVQIILESC 268

  Fly   185 FSGRPEMDIELRNTDPNAQYQVSIPMVEESIRRCL---LSAVT----NINLSEEMPEER--NTFA 240
            .:.      .|..|..:....::..:::|...||:   ::..|    .:..:|...:||  ..:.
Human   269 HNQ------NLLGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWR 327

  Fly   241 DTFSRTIYNPPT------------------HSPSGTMRNSYNNYDTNLHVDAY--------GTQS 279
            |      |.|||                  ::.:..::.:..:|.| :|:.:.        ..|.
Human   328 D------YVPPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKT-IHLSSIRPPRLEGDNIQD 385

  Fly   280 SHRSNSPSGDVPEMF------------KKLNES--HLISPSYNTNSIPNKMRIKVIKASRLGREV 330
            .::...|..|:|.||            ||:|.:  ::...|..|.::|..........:..|..:
Human   386 KNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGINI 450

  Fly   331 SQPFVNVEM-----------------DE----PAQKYSTTKGINAN------------------- 355
            ::..|:..:                 ||    .|:.....||:::.
Human   451 AEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAK 515

  Fly   356 ---PFWEETFDFDLTPATEEILFEIYEGND-KLHMNDDEGFLGLAIVNFEEIRRSGETVHSLKLQ 416
               ||.:.      ...:|.::..::.|:. ||::..:...:...:... |..|....:..|..:
Human   516 QFLPFLQR------AGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGI-ECPRGARNLPGLVQE 573

  Fly   417 GRPYRKDA--------ISGEITVQFDFFYDPNLLTSGKLTDTVKVTNPNGSEF--RETLT----T 467
            |.|:.::|        :..|:.|:.:     ::..:|.....:.:...|.|..  .:.|:    |
Human   574 GEPFSEEATLFTKELVLQREVEVEVE-----SMDKAGNFIGWLHMDGANLSVLLVEQALSKVHFT 633

  Fly   468 HRRPIYDPHDNFDGHEPIVPSKTTTVTVKTVSQTLKEKPTIQSVHGSLENAVDPATQKIL----- 527
            ..|..|        ::|::.::......|.......|:..::.|...||.....|:.|.:
Human   634 AERSAY--------YKPLLSAEEAAKQRKEKVWAHYEERPVEEVMPVLEEKERSASYKPVFVTEI 690

  Fly   528 --DRQFKNHNDPKTRELEAKLQSVAQSMSASSTLDRPSKNGN--------------NGQYYRDQ- 575
              |..|...:.....:||..::::...:|:     .|...|:              :|::||.:
Human   691 TDDLHFYVQDVETGTQLEKLMENMRNDISS-----HPPVEGSYAPRRGEFCIAKFVDGEWYRARV 750

  Fly   576 ----------------------------TAPPEFHEELDVRQSRDKSKKAPTEKRDRSF-FGELK 611
                                        |.||.|           .::..|.:..:.:| |.::.
Human   751 EKVESPAKVHVFYIDYGNREILPSTRLGTLPPAF-----------STRVLPAQATEYAFAFIQVP 804

  Fly   612 DRLSGRRGRSQKRSKSV-----DVENNQLLEEAVSLPPSRDPSRTRYAVSSNDKYRETHSVGGRS 671
            .       ....|:.:|     |::|.|.|.....|..|......::|.|..|       ||
Human   805 Q-------DEDARTDAVDSVVRDIQNTQCLLNVEHLSASCPHVTLQFADSKGD-------VG--- 852

  Fly   672 GESTKSLYQHSTLILELDQDKQAKYFLIPPAMLNEPAAS---RLMRKG 716
                ..|.:...:::|:.::||.:..:.......|.|.|   .|.|.|
Human   853 ----LGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYG 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	51/266 (19%)
		Homeodomain	255..311	CDD:459649	14/77 (18%)
		KLF1_2_4_N	<321..404	CDD:425360	14/126 (11%)
HOXC4	NP_055435.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..130		5/28 (18%)
		Antp-type hexapeptide	135..140		1/4 (25%)
		Homeodomain	157..213	CDD:459649	16/60 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..264		11/57 (19%)