Protein Alignment ftz and HOXA10

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_061824.3
• Gene: HOXA10 / 3206
• HGNCID: 5100
• Length: 410
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 113/620 - (18%)
• Similarity: 190/620 - (30%)
• Gaps: 194/620 - (31%)

  Fly   271 HVDAYGTQSS--------HRSNSPSGDVPEMFKKLNESHLISPSYNTNSIPNKMRIKVIKASRLG 327
            |.|..||||:        |.....:|..|...:..|:.|   ....::..|..:|..:::.:..|
Human   785 HCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQEH---KDETSSKAPMFIRPDILRGAFKG 846

  Fly   328 REVSQPFVNVEMDEPAQKYST---TKGINANPFWEETFDFDLTPATEEILFEIYEGNDKLHMNDD 389
                .|.::......:|:::.   :.|.::.         ..|....|:..:..:|:|
Human   847 ----LPGIDFRGGPASQQWTAGMLSSGDHSG---------QATGMPSELSSDALKGSD------- 891

  Fly   390 EGFLGLAIVNFEEIRRSGETVHSLKLQGRPYRKDAISGEITVQ--FDFFYDPNLLTSGKLTDT-- 450
               |.....::.||             ||.| ::.:|..:..|  ...|.|..:|:|.|..||
Human   892 ---LPSKSSHYSEI-------------GRAY-QNIVSNGVNFQGSLQAFMDSFVLSSLKKKDTKD 939

  Fly   451 --------VKVTNPNGSEFRETLTTHRRPI----YDPHD-NFDGHEPIVPSKTTTV--------- 493
                    :|.....|.|.:.::...:|..    |:|.| :.....|.:|..:.||
Human   940 KVPSDAHPMKAHTAEGGEEKASMKPSQRKSEKSQYEPLDLSVRPDAPTLPGSSVTVQDSIAWHGC 1004

  Fly   494 ---TVKTVSQTL---------------KEKPT-----------------------------IQSV 511
               ...|.|..|               |:.||                             :.|.
Human  1005 LFCAFTTSSMELMALHLQANHLGRAKRKDHPTGVTVNCKEQGREASKVSVLPSLQSNKEMALPSA 1069

  Fly   512 HGSLENAVD-----PATQKILD---RQFKNHNDPKTRELEA---KLQSVAQSMSASSTLDRPSKN 565
            .|.|::|.:     ||.:.:.|   .|:.||.||......:   |...|..:|..|.........
Human  1070 VGVLDSAPEKLAQGPAKETLGDPKSGQWPNHMDPAFCTFPSDFYKQFGVYPAMVGSGAPGSCLNK 1134

  Fly   566 GNNGQYYRDQTAPPEFHEELDVRQSRDKSKKAPTEKRDRSFFGELKDRLSGRRGRSQKRSKSVDV 630
            ...|:.:.|..||....|..:...:.|.|..|.:|..|.|            :|
Human  1135 NTEGKTHPDDDAPILIPETTNKNTTDDLSDIASSEDMDSS------------KG----------- 1176

  Fly   631 ENNQLLEEAVSLPPSRDPSRTRYAVSSNDKYRETHSVGGRSGESTKSLYQHSTLILELDQDKQAK 695
            |||:  :|.:    ..:|..|...:|:..|  :..|.||.|..|..:......|:..|.|..:.:
Human  1177 ENNE--DEEL----DTEPEMTSKPLSALSK--DGSSEGGDSLLSPGAPQPIQGLVSPLAQAAEEQ 1233

  Fly   696 YFL------------IPPAMLNEPAASRLMRKGKKLHIYNDHTFVAVKVKGGATCN--------V 740
            :..            :|......|...:.|.....|..|:.....|......:|.|        :
Human  1234 WHSPGLLPAQDPSAGLPKPERGPPGLEKPMSMLSVLRAYSADGLAAFNGLASSTANSGCIKRPDL 1298

  Fly   741 CQQRIRSSFSKQAYQCRDCKMVCHKTCHYKTDAFC 775
            |..|        .:||..|.....:..:.||...|
Human  1299 CGHR--------PFQCHYCPYSASQKGNLKTHVLC 1325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787
		Homeodomain	255..311	CDD:459649	11/47 (23%)
		KLF1_2_4_N	<321..404	CDD:425360	10/85 (12%)
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..158
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..339
		Homeodomain	337..393	CDD:459649