Protein Alignment ftz and TLX2

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_057254.1
• Gene: TLX2 / 3196
• HGNCID: 5057
• Length: 284
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 54/230 - (23%)
• Similarity: 76/230 - (33%)
• Gaps: 72/230 - (31%)

  Fly   174 YSPQSQTQKLKNGDFATP------PPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAP 232
            |.|......|.......|      |...|..:||..|  ..|..||                  |
Human    60 YGPAGSLAPLPGSSGVGPGGVIRVPAHRPLPVPPPAG--GAPAVPG------------------P 104

  Fly   233 NGAG--------DFNWSHIEETLASDCKDS-----------------------KRTRQTYTRYQT 266
            :|.|        .|.|.......|.|...:                       |:.|.:::|.|.
Human   105 SGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQV 169

  Fly   267 LELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAM-- 329
            ||||:.|...:|:....|..:|.||.:::.|:|.||||||.|.::....:...|...||...:
Human   170 LELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHL 234

  Fly   330 ----LP-PLEATSTATTGAPSVPVPMYHHHQTTAA 359
                || ||.        .|..|.|:..|:.:..|
Human   235 QQDALPRPLR--------PPLPPDPLCLHNSSLFA 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	17/87 (20%)
		Homeodomain	255..311	CDD:459649	23/55 (42%)
		KLF1_2_4_N	<321..404	CDD:425360	11/46 (24%)
TLX2	NP_057254.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..106		9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..166		2/26 (8%)
		Homeodomain	158..214	CDD:459649	23/55 (42%)