Protein Alignment ftz and HMX2

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_005510.1
• Gene: HMX2 / 3167
• HGNCID: 5018
• Length: 273
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 57/213 - (26%)
• Similarity: 89/213 - (41%)
• Gaps: 35/213 - (16%)

  Fly   172 DVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTP---PQSPGEKSSSAVSQEINHRIVTA-- 231
            |.:.|:.|..|     ...|.|......|...|.|.|   .::|....|.:..:|...|::.|
Human    69 DQHGPKEQGPK-----HHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEKERLLPAGS 128

  Fly   232 -------PNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIAN 289
                   |...|       .|..|...|  |:||..::|.|..:||..|...||::...|..:|:
Human   129 PSPGSERPRDGG-------AERQAGAAK--KKTRTVFSRSQVYQLESTFDMKRYLSSSERACLAS 184

  Fly   290 ALSLSERQIKIWFQNRRMKSKKDRTLD---SSPEHCGAGYTAMLPPLEATSTATTGAP-----SV 346
            :|.|:|.|:|.||||||.|.|:..:.:   ::..|..| .|.:..||....::....|     :.
Human   185 SLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASA-QTLVSMPLVFRDSSLLRVPVPRSLAF 248

  Fly   347 PVPMYHHHQTTAAYPAYS 364
            |.|:|:.....:|.|.|:
Human   249 PAPLYYPGSNLSALPLYN 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	18/87 (21%)
		Homeodomain	255..311	CDD:459649	24/55 (44%)
		KLF1_2_4_N	<321..404	CDD:425360	12/49 (24%)
HMX2	NP_005510.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..152		21/96 (22%)
		Homeodomain	150..206	CDD:459649	24/55 (44%)