Protein Alignment ftz and GBX2

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 88/406 - (21%)
• Similarity: 144/406 - (35%)
• Gaps: 142/406 - (34%)

  Fly     6 SQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVT 70
            |..|:.|. ...|:..|.|..|||
Human    35 SPGHFVYT-GYPMFMPYRPVVLPP----------------------------------------- 57

  Fly    71 TQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVK 135
                ||     |||.|..:.|...|..        |:       :|..::...|..|.:::.|
Human    58 ----PP-----PPPPALPQAALQPALP--------PA-------HPHHQIPSLPTGFCSSLAQ-- 96

  Fly   136 KAPAVSTKVTA------SPAPSYDQ-----EYVTVPTPSASEDVDYLDVYSPQSQTQK---LKNG 186
             ..|:::.:.|      |.:|.:.:     ::...|.|... :.|..:.....::..|   .|.|
Human    97 -GMALTSTLMATLPGGFSASPQHQEAAAARKFAPQPLPGGG-NFDKAEALQADAEDGKGFLAKEG 159

  Fly   187 D---FATPPPTTPTSLPPLEG-------ISTPPQSPGEKSSSAVSQEINHRI---VTAPNGAGDF 238
            .   |:.......:.:..:.|       :...|:  |::.|.::..::::..   :|......:.
Human   160 SLLAFSAAETVQASLVGAVRGQGKDESKVEDDPK--GKEESFSLESDVDYSSDDNLTGQAAHKEE 222

  Fly   239 NWSH-IEETLAS--------DCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLS 294
            :..| :|||..|        ....::|.|..:|..|.||||||||..:|::...|..||:||.||
Human   223 DPGHALEETPPSSGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLS 287

  Fly   295 ERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAPS------VPVPMY-- 351
            |.|:||||||||.|.|:.:          ||          .:.:.||.||      ||:|::
Human   288 EVQVKIWFQNRRAKWKRVK----------AG----------NANSKTGEPSRNPKIVVPIPVHVS 332

  Fly   352 ------HHHQTTAAYP 361
                  .|.|...|.|
Human   333 RFAIRSQHQQLEQARP 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	42/269 (16%)
		Homeodomain	255..311	CDD:459649	31/55 (56%)
		KLF1_2_4_N	<321..404	CDD:425360	13/55 (24%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		11/73 (15%)
		Homeodomain	248..304	CDD:459649	31/55 (56%)