Protein Alignment ftz and NKX2-8

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_055175.2
• Gene: NKX2-8 / 26257
• HGNCID: 16364
• Length: 239
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 74/294 - (25%)
• Similarity: 105/294 - (35%)
• Gaps: 111/294 - (37%)

  Fly   108 TLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLD 172
            |:|:||..|.:..::.|                    ...|.|...|     |.|.|:    :||
Human    10 TVRSLLDLPEQDAQHLP--------------------RREPEPRAPQ-----PDPCAA----WLD 45

  Fly   173 V---YSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNG 234
            .   :.|.|....|:     |.||  .:|..|    |..|.|||
Human    46 SERGHYPSSDESSLE-----TSPP--DSSQRP----SARPASPG--------------------- 78

  Fly   235 AGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIK 299
                          ||.:..|:.|..:::.||||||:.|...||::...|..:|:.|.|:..|:|
Human    79 --------------SDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVK 129

  Fly   300 IWFQNRRMKSKKDRT--------LDSSPE-HCGAGY--TAMLPPL----------------EATS 337
            |||||.|.|.|:.|.        |.:|.| |...|.  ..::|.|                .|.:
Human   130 IWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAA 194

  Fly   338 TATTGAP---SVPVPMYHHHQTTAA---YPAYSH 365
            ....|||   :.|:|.|......:|   :|||.|
Human   195 QEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQH 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	27/142 (19%)
		Homeodomain	255..311	CDD:459649	24/55 (44%)
		KLF1_2_4_N	<321..404	CDD:425360	16/69 (23%)
NKX2-8	NP_055175.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		30/151 (20%)
		Homeodomain	85..141	CDD:459649	24/55 (44%)