DRSC/TRiP Functional Genomics Resources

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Protein Alignment ftz and Hoxc10

DIOPT Version :10

Sequence 1:NP_477498.1 Gene:ftz / 40834 FlyBaseID:FBgn0001077 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_034592.2 Gene:Hoxc10 / 209448 MGIID:96192 Length:342 Species:Mus musculus


Alignment Length:361 Identity:93/361 - (25%)
Similarity:131/361 - (36%) Gaps:112/361 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 PHSLPPTYYDN-----SGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVTTQTVPPVQPTTPP 83
            |.::.|..|..     .|...|.:|.    |.|.|.....:|              ..::.....
Mouse     4 PRNVTPNSYAEPLAAPGGGERYNRNA----GMYMQSGSDFNC--------------GVMRGCGLA 50

  Fly    84 PKATKRKAEDDAASIIAAVEERPSTLRAL---------------LTNPVKKLKYTPDY------- 126
            |..:||   |:..|...|:...||.|..|               :..|:....|.|..       
Mouse    51 PSLSKR---DEGGSPNLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCC 112

  Fly   127 FYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPS---ASEDVDYLD---------------- 172
            .|:..::.|..|..:  :.:.|.|........||.||   ||.....||                
Mouse   113 MYSAEKRAKSGPEAA--LYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCAGANEFEAPFE 175

  Fly   173 -----------VYSPQ-------SQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEK---- 215
                       :.|||       .:|.|   .|..||   :|..:...:.::.|..||.|.    
Mouse   176 QRASLNPRTEHLESPQLGGKVSFPETPK---SDSQTP---SPNEIKTEQSLAGPKASPSESEKER 234

  Fly   216 -----SSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHF 275
                 ||...|.......:.|.|..|  ||        ...|..::.|..||::|||||||||.|
Mouse   235 AKTADSSPDTSDNEAKEEIKAENTTG--NW--------LTAKSGRKKRCPYTKHQTLELEKEFLF 289

  Fly   276 NRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
            |.|:||.||::|:..::|::||:||||||||||.||
Mouse   290 NMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKK 325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftzNP_477498.1 FTZ 1..248 CDD:397787 57/296 (19%)
Homeodomain 255..311 CDD:459649 33/55 (60%)
KLF1_2_4_N <321..404 CDD:425360
Hoxc10NP_034592.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 3/15 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..271 22/100 (22%)
Homeodomain 269..325 CDD:459649 33/55 (60%)
Blue background indicates that the domain is not in the aligned region.

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