Protein Alignment ftz and EN2

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001418.2
• Gene: EN2 / 2020
• HGNCID: 3343
• Length: 333
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 56/216 - (25%)
• Similarity: 75/216 - (34%)
• Gaps: 72/216 - (33%)

  Fly   192 PPTTPTSLPPLEGISTPPQSPGEKSSSAVSQE------------INHRIVTAPNGAGDFNWSHIE 244
            ||..|.:..||....:.....||..|..:|..            ::..:.....|.||.:.|...
Human   133 PPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDS 197

  Fly   245 E---------------------TLASD----------------CKDSKRTRQTYTRYQTLELEKE 272
            :                     |..||                .|:.||.|..:|..|...|:.|
Human   198 DSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAE 262

  Fly   273 FHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATS 337
            |..|||:|.:||..:|..|||:|.||||||||:|.|.||                       ||.
Human   263 FQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKK-----------------------ATG 304

  Fly   338 TATTGAPSVPVPMYHHHQTTA 358
            ...|.|..:.....::|.|||
Human   305 NKNTLAVHLMAQGLYNHSTTA 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	14/88 (16%)
		Homeodomain	255..311	CDD:459649	29/55 (53%)
		KLF1_2_4_N	<321..404	CDD:425360	8/38 (21%)
EN2	NP_001418.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..206		13/72 (18%)
		homeobox domain	243..302		31/81 (38%)
		Homeodomain	245..301	CDD:459649	29/55 (53%)
		Engrail_1_C_sig	302..332	CDD:431338	8/24 (33%)