Protein Alignment ftz and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 270
• Identity: 65/270 - (24%)
• Similarity: 103/270 - (38%)
• Gaps: 49/270 - (18%)

  Fly    75 PPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLR-------ALLTNPVKKLKYTPDYFYTTVE 132
            ||: ||.||..::...:....:..:.:  ..|..|:       :.|.:|.::|.....:....:.
Mouse    41 PPL-PTGPPSSSSSSSSSSSPSPPLGS--HNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDIL 102

  Fly   133 QVKKAPAVSTKV--TASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTT 195
            .....|..|...  :|||:.|......:....||          |..:..........|:.|...
Mouse   103 SRPSMPVASGAALPSASPSGSSSSSSSSASATSA----------SAAAAAAAAAAAAAASSPAGL 157

  Fly   196 PTSLPPLEGISTPPQSPG---EKSSSAVSQ--EINHRIVTAPNGAGDFNWSHIEET-------LA 248
            ...||....:|.||..||   ..|::||:.  .....:...| |.....|..:.::       ||
Mouse   158 LAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELP-GRTPIFWPGVMQSPPWRDARLA 221

  Fly   249 SDC----------KDSKR--TRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIW 301
              |          ||.||  ||.|::..|...|||.|...:|:....|..:|.:|.::|.|:|:|
Mouse   222 --CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVW 284

  Fly   302 FQNRRMKSKK 311
            |||||.|.:|
Mouse   285 FQNRRTKWRK 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	35/193 (18%)
		Homeodomain	255..311	CDD:459649	24/57 (42%)
		KLF1_2_4_N	<321..404	CDD:425360
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		17/97 (18%)
		Repressor domain. /evidence=ECO:0000250	102..269		41/179 (23%)
		Homeodomain	236..294	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		65/270 (24%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365