Protein Alignment ftz and Nkx2-6

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_035050.2
• Gene: Nkx2-6 / 18092
• MGIID: 97351
• Length: 289
• Species: Mus musculus
• Alignment Length: 272
• Identity: 67/272 - (24%)
• Similarity: 103/272 - (37%)
• Gaps: 83/272 - (30%)

  Fly   146 ASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQK----------------------LKNGDF 188
            :||..|         ||.:..|:..|:.....|:|..                      .::.|.
Mouse     3 SSPVAS---------TPFSVADILRLECQQKDSKTLSQWELHRNPVKPRYLRMNQESGWFESSDR 58

  Fly   189 ATPPPTTPTSLPPLEGISTP---PQS-PGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLAS 249
            |...|...|....||..|.|   ||: ||..|.......:..|.|  .|.:||....   ..:::
Mouse    59 AQAVPFRCTWETVLEMGSNPVGEPQTPPGTISRLGARNPMTDRGV--GNLSGDMRRG---GPVST 118

  Fly   250 DCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSK---K 311
            ..:..:::|..:::.|.|.||:.|...||:|...|..:|:||.|:..|:||||||||.|||   :
Mouse   119 RTRPQRKSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQLTSTQVKIWFQNRRYKSKSQRQ 183

  Fly   312 DRTLD-------------------------------------SSPEHCGAGYTAMLPPLEAT-ST 338
            |:||:                                     :||..|..||..  .|.:|: ::
Mouse   184 DQTLELAGHPLAPRRVAVPVLVLDGKPCLDPDVAAFLGPYKATSPYSCFGGYAG--TPYDASYAS 246

  Fly   339 ATTGAPSVPVPM 350
            ..|.|.:.|.|:
Mouse   247 RCTSASAGPGPL 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	27/127 (21%)
		Homeodomain	255..311	CDD:459649	26/58 (45%)
		KLF1_2_4_N	<321..404	CDD:425360	9/31 (29%)
Nkx2-6	NP_035050.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..125		12/54 (22%)
		Homeodomain	124..179	CDD:459649	24/54 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..289		67/272 (25%)