Protein Alignment ftz and NKX6-3

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001351770.1
• Gene: NKX6-3 / 157848
• HGNCID: 26328
• Length: 265
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 66/328 - (20%)
• Similarity: 118/328 - (35%)
• Gaps: 94/328 - (28%)

  Fly   519 VDPATQKILDRQFKNHNDP--KTREL----------------EAKLQSVAQSMSASSTLDRPSKN 565
            |:..|....||..|:..:|  :.|:|                |.|.:::....|....:::..:.
Human   164 VEDGTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFKNEIKKENLKWDDSEEVEINKALQR 228

  Fly   566 GNNGQYYRDQTAPPEFHEELDVRQSR----DKSKKAPTEKR--DRSFFGELKDRLSGRRGRSQKR 624
            .:.|.|:..:.......|....||.|    :..:|.|::::  .:||..  :|:........:..
Human   229 KSRGVYWHSELQKGLESEPTSRRQCRNSPGESEEKTPSQEKMSHQSFCA--RDKACTHILCGKNC 291

  Fly   625 SKSVDVENNQLLE-EAVSLPP--SRDPSRTRYAV------------------------SSNDKYR 662
            |:||...:...|: |.||..|  .:..||:.|.|                        |:...:.
Human   292 SQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHL 356

  Fly   663 ETHSVGGR---SGESTKSLYQHSTLILELDQDKQAKYFLIPPAMLNEPAASRLMRKGKKLHIYND 724
            .||: |.|   .|:..||..|.|:||:........|.:             :.:..||:.:  |.
Human   357 RTHT-GERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPY-------------QCIVCGKRFN--NS 405

  Fly   725 HTFVA-VKVKGGAT---CNVCQQRIRSS--FS--------KQAYQCRDCK--------MVCHKTC 767
            ..|.| .::..|.:   |.||.:...:|  ||        ::.|:|..|:        :..|:|.
Human   406 SQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTV 470

  Fly   768 HYK 770
            |.|
Human   471 HMK 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787
		Homeodomain	255..311	CDD:459649
		KLF1_2_4_N	<321..404	CDD:425360
NKX6-3	NP_001351770.1	Homeodomain	138..196	CDD:459649	8/31 (26%)