Protein Alignment ftz and NKX2-5

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_004378.1
• Gene: NKX2-5 / 1482
• HGNCID: 2488
• Length: 324
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 71/287 - (24%)
• Similarity: 107/287 - (37%)
• Gaps: 70/287 - (24%)

  Fly   148 PAPSYDQEYVTVPTPSASEDVDYLD------------------VYSPQS-QTQKLKNGDFATPPP 193
            |:|:      ..|||.:.:|:..|:                  ..:|.| .....|...:|.|..
Human     3 PSPA------LTPTPFSVKDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAAFKPEAYAGPEA 61

  Fly   194 TTPTSLPPLEGISTPPQSPGEKSSS-AVSQEINHRIVTAPNGAGDFNWS-----------HIEET 246
            ..| .||.|........||.:.:|: ..:.....|..:.|:.|.|....           .:|:|
Human    62 AAP-GLPELRAELGRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCALQKAVELEKT 125

  Fly   247 LASD-----CKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRR 306
            .|.:     .:..::.|..:::.|..|||:.|...||::...|..:|:.|.|:..|:||||||||
Human   126 EADNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRR 190

  Fly   307 MKSKKDRTLDSSPEHCGAGYTAMLPP--------LEATSTATTGAP----SVP-VPMY------H 352
            .|.|:.|. |.:.|..|      |||        :........|.|    |.| .|.|      :
Human   191 YKCKRQRQ-DQTLELVG------LPPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPAYGVGLNPY 248

  Fly   353 HHQTTAAYPAYSHSH-SHGYGLLNDYP 378
            .:....|||.|..:. |.||.....||
Human   249 GYNAYPAYPGYGGAACSPGYSCTAAYP 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	25/130 (19%)
		Homeodomain	255..311	CDD:459649	22/55 (40%)
		KLF1_2_4_N	<321..404	CDD:425360	19/78 (24%)
NKX2-5	NP_004378.1	Homeodomain	145..195	CDD:459649	21/49 (43%)