Protein Alignment ftz and NKX2-6

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 76/334 - (22%)
• Similarity: 114/334 - (34%)
• Gaps: 112/334 - (33%)

  Fly   112 LLTNPVKKLKYT-PDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYL--DV 173
            :|.:||....:: .|..  .:|:.:..||      |||.|.         ...:.|:..||  |.
Human     1 MLLSPVTSTPFSVKDIL--RLERERSCPA------ASPHPR---------VRKSPENFQYLRMDA 48

  Fly   174 YSPQSQTQKLKNG------DFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAP 232
            ....|:......|      |.:.||.....::..::........||..::|             |
Human    49 EPRGSEVHNAGGGGGDRKLDGSEPPGGPCEAVLEMDAERMGEPQPGLNAAS-------------P 100

  Fly   233 NGAGDFNWSHIEETLASDCKDS--------------KRTRQTYTRYQTLELEKEFHFNRYITRRR 283
            .|.|    :.:.|....:..||              ::.|..:::.|.|.||:.|...||::...
Human   101 LGGG----TRVPERGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLALERRFKQQRYLSAPE 161

  Fly   284 RIDIANALSLSERQIKIWFQNRRMKSKK---DRTLD----------------------------- 316
            |..:|:||.|:..|:||||||||.|.|:   |::|:
Human   162 REHLASALQLTSTQVKIWFQNRRYKCKRQRQDKSLELAGHPLTPRRVAVPVLVRDGKPCLGPGPG 226

  Fly   317 -----------SSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHG 370
                       .||..|..||:. .|......|...||||.|.|    |...|       |...|
Human   227 APAFPSPYSAAVSPYSCYGGYSG-APYGAGYGTCYAGAPSGPAP----HTPLA-------SAGFG 279

  Fly   371 YGLLNDYPQ 379
            :|..|..||
Human   280 HGGQNATPQ 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	27/144 (19%)
		Homeodomain	255..311	CDD:459649	23/55 (42%)
		KLF1_2_4_N	<321..404	CDD:425360	19/59 (32%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		24/144 (17%)
		Homeodomain	133..189	CDD:459649	23/55 (42%)