Protein Alignment ftz and Cdx2

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_031699.2
• Gene: Cdx2 / 12591
• MGIID: 88361
• Length: 311
• Species: Mus musculus
• Alignment Length: 270
• Identity: 75/270 - (27%)
• Similarity: 110/270 - (40%)
• Gaps: 70/270 - (25%)

  Fly   124 PDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSP------QSQTQK 182
            |||....|.....|.| :.....||.||:       ||...:...:..:.|:|      .:....
Mouse    38 PDYGGYHVAAAAAATA-NLDSAQSPGPSW-------PTAYGAPLREDWNGYAPGGAAAANAVAHG 94

  Fly   183 LKNGD------FATPP-----------PTTPTSLPP-----LEGISTPPQSPGEKSSSAVSQEIN 225
            |..|.      :::|.           |..|.:.|.     |:.::..|  ||..:::|..|
Mouse    95 LNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGP--PGPAATAAAEQ--- 154

  Fly   226 HRIVTAPNG--AGDFNWSH--IEETLASDCK--DSKRTRQTYTRYQTLELEKEFHFNRYITRRRR 284
                .:|:|  .....|..  .:::|.|..|  ...:.|..||.:|.|||||||||:||||.||:
Mouse   155 ----LSPSGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRK 215

  Fly   285 IDIANALSLSERQIKIWFQNRRMKSKK---------DRTLDSSPEHCGAGYTAMLPPLEATSTAT 340
            .::|..|.|||||:||||||||.|.:|         .:.....|:          ||.:.:....
Mouse   216 SELAATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQ----------PPPQPSQPQP 270

  Fly   341 TGAPSVPVPM 350
            ....|||.|:
Mouse   271 GALRSVPEPL 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	29/155 (19%)
		Homeodomain	255..311	CDD:459649	35/55 (64%)
		KLF1_2_4_N	<321..404	CDD:425360	6/30 (20%)
Cdx2	NP_031699.2	Caudal_act	13..178	CDD:461413	30/156 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..151		7/41 (17%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626	185..215		18/29 (62%)
		Homeodomain	187..242	CDD:459649	35/54 (65%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626	227..241		11/13 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..311		9/52 (17%)
		4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724	281..293		75/270 (28%)