DRSC/TRiP Functional Genomics Resources

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Protein Alignment ftz and CDX2

DIOPT Version :10

Sequence 1:NP_477498.1 Gene:ftz / 40834 FlyBaseID:FBgn0001077 Length:410 Species:Drosophila melanogaster
Sequence 2:XP_011533177.1 Gene:CDX2 / 1045 HGNCID:1806 Length:321 Species:Homo sapiens


Alignment Length:235 Identity:67/235 - (28%)
Similarity:95/235 - (40%) Gaps:68/235 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 PDY--FYTTVEQVKKAPAVSTKVTASPAPSYDQEY--------------------------VTVP 160
            |||  ::..   ...|.|.:.....||.||:...|                          :...
Human    38 PDYGGYHVA---AAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGG 99

  Fly   161 TPSA----SEDVDYLDVYSPQ------SQTQKLKNGDFAT--PPPTTPTSLPPLEGISTPPQSPG 213
            :|:|    |...||...:.|.      :......:|...|  |.|..|.:....|.:     |||
Human   100 SPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQL-----SPG 159

  Fly   214 -------EKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEK 271
                   |.......|.:..:.:|:|:           .|:.:..||  :.|..||.:|.|||||
Human   160 GQRRNLCEWMRKPAQQSLGSQALTSPS-----------STVKTRTKD--KYRVVYTDHQRLELEK 211

  Fly   272 EFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
            |||::||||.||:.::|..|.|||||:||||||||.|.:|
Human   212 EFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERK 251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftzNP_477498.1 FTZ 1..248 CDD:397787 30/170 (18%)
Homeodomain 255..311 CDD:459649 34/55 (62%)
KLF1_2_4_N <321..404 CDD:425360
CDX2XP_011533177.1 Caudal_act 13..179 CDD:461413 27/148 (18%)
Homeodomain 196..251 CDD:459649 34/54 (63%)
Blue background indicates that the domain is not in the aligned region.

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